Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut

Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut

Abstract There is an urgent need for novel methods that can accurately predict intestinal absorption of orally administered drugs in humans. This study aimed to evaluate the potential of a novel gut microphysiological system (MPS), gut MPS/Fluid3D-X, to assess the intestinal absorption of drugs in h...

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Main Authors: Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, Kempei Tai, Mitsuharu Ishii, Ayaka Nozue, Ikuko Kaisaki, Misa Hoshi, Kengo Watanabe, Kazuya Maeda, Takashi Kamizono, Takahiro Yoshioka, Takashi Fujimoto, Taku Satoh, Hiroko Nakamura, Osamu Ando, Hiroyuki Kusuhara, Yuzuru Ito
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-80946-6
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