The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development

The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development

Summary: Eliminating redundant synapses formed around birth is essential for shaping functionally mature neural circuits during postnatal development. Each Purkinje cell (PC) in the neonatal mouse cerebellum receives synaptic inputs from multiple climbing fibers (CFs). Only one CF is strengthened an...

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Bibliographic Details
Main Authors: Jianling Zhang, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Kohtarou Konno, Yuto Okuno, Kyoko Matsuyama, Takayuki Noro, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Molecular physiology
Neuroscience
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225010077
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