Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations
Over the past decade, dioxazolones have been widely used as N-acylamide sources in amidation processes of challenging substrates, typically employing precious transition metals. However, these catalytic systems often present several challenges associated with cost, toxicity, stability, and recyclabi...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.21.12 |
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| _version_ | 1832544821978333184 |
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| author | Seungmin Lee Minsuk Kim Hyewon Han Jongwoo Son |
| author_facet | Seungmin Lee Minsuk Kim Hyewon Han Jongwoo Son |
| author_sort | Seungmin Lee |
| collection | DOAJ |
| description | Over the past decade, dioxazolones have been widely used as N-acylamide sources in amidation processes of challenging substrates, typically employing precious transition metals. However, these catalytic systems often present several challenges associated with cost, toxicity, stability, and recyclability. Among the 3d transition metals, copper catalysts have been gaining increasing attention owing to their abundance, cost-effectiveness, and sustainability. Recently, these catalytic systems have been applied to the chemical transformation of dioxazolones, conferring a convenient protocol towards amidated products. This review highlights recent advancements in the synthetic transformations of dioxazolones, with particular examples of copper salts. |
| format | Article |
| id | doaj-art-6a1982e6cb9e4d9aa2933c7a34b54562 |
| institution | Kabale University |
| issn | 1860-5397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-6a1982e6cb9e4d9aa2933c7a34b545622025-02-03T09:10:17ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-01-0121120021610.3762/bjoc.21.121860-5397-21-12Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformationsSeungmin Lee0Minsuk Kim1Hyewon Han2Jongwoo Son3Department of Chemistry, Dong-A University, Busan 49315, South Korea Department of Chemical Engineering (BK21 FOUR Graduate Program), Dong-A University, Busan 49315, South Korea Department of Chemistry, Dong-A University, Busan 49315, South Korea Department of Chemistry, Dong-A University, Busan 49315, South Korea Over the past decade, dioxazolones have been widely used as N-acylamide sources in amidation processes of challenging substrates, typically employing precious transition metals. However, these catalytic systems often present several challenges associated with cost, toxicity, stability, and recyclability. Among the 3d transition metals, copper catalysts have been gaining increasing attention owing to their abundance, cost-effectiveness, and sustainability. Recently, these catalytic systems have been applied to the chemical transformation of dioxazolones, conferring a convenient protocol towards amidated products. This review highlights recent advancements in the synthetic transformations of dioxazolones, with particular examples of copper salts.https://doi.org/10.3762/bjoc.21.12amidationcopper saltsdioxazoloneselectrophilic nitrogenn-acyl nitrene |
| spellingShingle | Seungmin Lee Minsuk Kim Hyewon Han Jongwoo Son Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations Beilstein Journal of Organic Chemistry amidation copper salts dioxazolones electrophilic nitrogen n-acyl nitrene |
| title | Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations |
| title_full | Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations |
| title_fullStr | Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations |
| title_full_unstemmed | Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations |
| title_short | Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations |
| title_sort | dioxazolones as electrophilic amide sources in copper catalyzed and mediated transformations |
| topic | amidation copper salts dioxazolones electrophilic nitrogen n-acyl nitrene |
| url | https://doi.org/10.3762/bjoc.21.12 |
| work_keys_str_mv | AT seungminlee dioxazolonesaselectrophilicamidesourcesincoppercatalyzedandmediatedtransformations AT minsukkim dioxazolonesaselectrophilicamidesourcesincoppercatalyzedandmediatedtransformations AT hyewonhan dioxazolonesaselectrophilicamidesourcesincoppercatalyzedandmediatedtransformations AT jongwooson dioxazolonesaselectrophilicamidesourcesincoppercatalyzedandmediatedtransformations |