Efectiveness and safety of very low calory diets in obese patients
Purpose: To evaluate effectiveness, safety and adherence of Very Low Calory Diet (VLCD) in patients with obesity. Methods: Observational prospective descriptive study. Patients with BMI >30 kg/m2 who started VLCD were included. We arranged 3 pharmacotherapeutical consultations, picking up the v...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
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| Series: | Farmacia Hospitalaria |
| Subjects: | |
| Online Access: | http://www.aulamedica.es/fh/pdf/978.pdf |
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| Summary: | Purpose: To evaluate effectiveness, safety and adherence of Very Low Calory Diet (VLCD) in patients with obesity.
Methods: Observational prospective descriptive study. Patients with BMI >30 kg/m2 who started VLCD were included. We arranged 3 pharmacotherapeutical consultations, picking up the variables: age, sex, BMI, side effects and number of VLCD cycles. We defined effectiveness as weight loss in absolute and relative terms and weight loss rate (kg/week); safety as incidence and severity of side effects by the Farmacovigilance Spanish System (SEFV); and adherence by a SMAQ adapted questionnaire.
Results: 29 women and 15 men were included, with a mean of 42 years. 5 patients did not complete the follow-up. Effectiveness: weight loss average was 7kg (IQR 9,5 a 5,3) and relative of 6,7%, (p < 0.0005). The weight loss rate was 1,2kg per week (IQR 1,6 a 0,9). Safety: 33% of the patients described side effects. All of them were mild (37% constipation, 16% dizziness, 12% anxiety, 5% headache, 2% gases y 2% epigastrical pain). Adherence: 84% of the patients were adherent by the SMAQ adapted questionnaire: 74% in the first cycle and 92% in the following ones. The relation between the number of cycles and the adherence did not get statistical differences (p = 0,1127).
Conclusions: Effectiveness and adherence to the treatment could improve in obese patients by setting interdisciplinary measures in the daily clinical practice. |
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| ISSN: | 1130-6343 2171-8695 |