Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients
Abstract Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1‐3A. Early failure was described as failing to achieve event‐free su...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70117 |
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| author | Cong Li Na Guo Shuiyun Han Haifeng Yu Tao Lei Xi Chen Shuailing Peng Haiyan Yang Meijuan Wu |
| author_facet | Cong Li Na Guo Shuiyun Han Haifeng Yu Tao Lei Xi Chen Shuailing Peng Haiyan Yang Meijuan Wu |
| author_sort | Cong Li |
| collection | DOAJ |
| description | Abstract Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1‐3A. Early failure was described as failing to achieve event‐free survival (EFS) at 12 or 24 months. Results There were 49 (47.6%) male and 54 (52.4%) females, with a median age of 54 years. Compared to patients with <20% of positive CD4 cells, patients with ≥20% of positive CD4 cells exhibited a significant lower risk of early failure (2‐year EFS rate: 56.7% vs 73.5%, p = 0.047). When patients were stratified based on positive CD4 cell combined with FLIPI, the median EFS (p = 0.002) and median OS (p = 0.007) were significantly different. Conclusions This study demonstrated that higher expression of positive CD4 cells predicts lower risk of early failure in follicular lymphoma, and combination analysis of CD4 and FLIPI could better predict disease relapse and survival outcome. |
| format | Article |
| id | doaj-art-6a1251f0b2fa43ffa6a522036a7f002c |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-6a1251f0b2fa43ffa6a522036a7f002c2025-02-07T09:08:08ZengWileyCancer Medicine2045-76342024-09-011317n/an/a10.1002/cam4.70117Impact of positive CD4 cells on event‐free survival in follicular lymphoma patientsCong Li0Na Guo1Shuiyun Han2Haifeng Yu3Tao Lei4Xi Chen5Shuailing Peng6Haiyan Yang7Meijuan Wu8Department of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Pathology, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaDepartment of Pathology, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang ChinaAbstract Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1‐3A. Early failure was described as failing to achieve event‐free survival (EFS) at 12 or 24 months. Results There were 49 (47.6%) male and 54 (52.4%) females, with a median age of 54 years. Compared to patients with <20% of positive CD4 cells, patients with ≥20% of positive CD4 cells exhibited a significant lower risk of early failure (2‐year EFS rate: 56.7% vs 73.5%, p = 0.047). When patients were stratified based on positive CD4 cell combined with FLIPI, the median EFS (p = 0.002) and median OS (p = 0.007) were significantly different. Conclusions This study demonstrated that higher expression of positive CD4 cells predicts lower risk of early failure in follicular lymphoma, and combination analysis of CD4 and FLIPI could better predict disease relapse and survival outcome.https://doi.org/10.1002/cam4.70117CD4+event‐free survivalfollicular lymphomaimmunohistochemistryprognosis |
| spellingShingle | Cong Li Na Guo Shuiyun Han Haifeng Yu Tao Lei Xi Chen Shuailing Peng Haiyan Yang Meijuan Wu Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients Cancer Medicine CD4+ event‐free survival follicular lymphoma immunohistochemistry prognosis |
| title | Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients |
| title_full | Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients |
| title_fullStr | Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients |
| title_full_unstemmed | Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients |
| title_short | Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients |
| title_sort | impact of positive cd4 cells on event free survival in follicular lymphoma patients |
| topic | CD4+ event‐free survival follicular lymphoma immunohistochemistry prognosis |
| url | https://doi.org/10.1002/cam4.70117 |
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