Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study
Background. Functional magnetic resonance imaging (fMRI) is a promising method for quantifying brain recovery and investigating the intervention-induced changes in corticomotor excitability after stroke. This study aimed to evaluate cortical reorganization subsequent to virtual reality-enhanced trea...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2017/6261479 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555053684097024 |
|---|---|
| author | Xiang Xiao Qiang Lin Wai-Leung Lo Yu-Rong Mao Xin-chong Shi Ryan S. Cates Shu-Feng Zhou Dong-Feng Huang Le Li |
| author_facet | Xiang Xiao Qiang Lin Wai-Leung Lo Yu-Rong Mao Xin-chong Shi Ryan S. Cates Shu-Feng Zhou Dong-Feng Huang Le Li |
| author_sort | Xiang Xiao |
| collection | DOAJ |
| description | Background. Functional magnetic resonance imaging (fMRI) is a promising method for quantifying brain recovery and investigating the intervention-induced changes in corticomotor excitability after stroke. This study aimed to evaluate cortical reorganization subsequent to virtual reality-enhanced treadmill (VRET) training in subacute stroke survivors. Methods. Eight participants with ischemic stroke underwent VRET for 5 sections per week and for 3 weeks. fMRI was conducted to quantify the activity of selected brain regions when the subject performed ankle dorsiflexion. Gait speed and clinical scales were also measured before and after intervention. Results. Increased activation in the primary sensorimotor cortex of the lesioned hemisphere and supplementary motor areas of both sides for the paretic foot (p<0.01) was observed postintervention. Statistically significant improvements were observed in gait velocity (p<0.05). The change in voxel counts in the primary sensorimotor cortex of the lesioned hemisphere is significantly correlated with improvement of 10 m walk time after VRET (r=−0.719). Conclusions. We observed improved walking and increased activation in cortical regions of stroke survivors after VRET training. Moreover, the cortical recruitment was associated with better walking function. Our study suggests that cortical networks could be a site of plasticity, and their recruitment may be one mechanism of training-induced recovery of gait function in stroke. This trial is registered with ChiCTR-IOC-15006064. |
| format | Article |
| id | doaj-art-6a043652bdfd4341ae42056505be5622 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-6a043652bdfd4341ae42056505be56222025-02-03T05:49:45ZengWileyBehavioural Neurology0953-41801875-85842017-01-01201710.1155/2017/62614796261479Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary StudyXiang Xiao0Qiang Lin1Wai-Leung Lo2Yu-Rong Mao3Xin-chong Shi4Ryan S. Cates5Shu-Feng Zhou6Dong-Feng Huang7Le Li8Department of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USADepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USADepartment of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBackground. Functional magnetic resonance imaging (fMRI) is a promising method for quantifying brain recovery and investigating the intervention-induced changes in corticomotor excitability after stroke. This study aimed to evaluate cortical reorganization subsequent to virtual reality-enhanced treadmill (VRET) training in subacute stroke survivors. Methods. Eight participants with ischemic stroke underwent VRET for 5 sections per week and for 3 weeks. fMRI was conducted to quantify the activity of selected brain regions when the subject performed ankle dorsiflexion. Gait speed and clinical scales were also measured before and after intervention. Results. Increased activation in the primary sensorimotor cortex of the lesioned hemisphere and supplementary motor areas of both sides for the paretic foot (p<0.01) was observed postintervention. Statistically significant improvements were observed in gait velocity (p<0.05). The change in voxel counts in the primary sensorimotor cortex of the lesioned hemisphere is significantly correlated with improvement of 10 m walk time after VRET (r=−0.719). Conclusions. We observed improved walking and increased activation in cortical regions of stroke survivors after VRET training. Moreover, the cortical recruitment was associated with better walking function. Our study suggests that cortical networks could be a site of plasticity, and their recruitment may be one mechanism of training-induced recovery of gait function in stroke. This trial is registered with ChiCTR-IOC-15006064.http://dx.doi.org/10.1155/2017/6261479 |
| spellingShingle | Xiang Xiao Qiang Lin Wai-Leung Lo Yu-Rong Mao Xin-chong Shi Ryan S. Cates Shu-Feng Zhou Dong-Feng Huang Le Li Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study Behavioural Neurology |
| title | Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study |
| title_full | Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study |
| title_fullStr | Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study |
| title_full_unstemmed | Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study |
| title_short | Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study |
| title_sort | cerebral reorganization in subacute stroke survivors after virtual reality based training a preliminary study |
| url | http://dx.doi.org/10.1155/2017/6261479 |
| work_keys_str_mv | AT xiangxiao cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT qianglin cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT waileunglo cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT yurongmao cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT xinchongshi cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT ryanscates cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT shufengzhou cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT dongfenghuang cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy AT leli cerebralreorganizationinsubacutestrokesurvivorsaftervirtualrealitybasedtrainingapreliminarystudy |