Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes
Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with immune system dysregulation playing a key role in its pathogenesis. Cytokines such as IFN-γ and IL-4 are critical in modulating the Th1/Th2 balance, which is implicated in the disease’s progression. This study aimed to eva...
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SAGE Publishing
2025-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X251342431 |
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| author | Xiang Zhao Yan Du Huabing Ge |
| author_facet | Xiang Zhao Yan Du Huabing Ge |
| author_sort | Xiang Zhao |
| collection | DOAJ |
| description | Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with immune system dysregulation playing a key role in its pathogenesis. Cytokines such as IFN-γ and IL-4 are critical in modulating the Th1/Th2 balance, which is implicated in the disease’s progression. This study aimed to evaluate the expression of IFN-γ and IL-4 in the peripheral blood of OLP patients and explore differences between erosive and non-erosive subtypes. Materials and Methods: A retrospective analysis included 58 OLP patients (30 non-erosive and 28 erosive) and 58 healthy controls enrolled from June 2020 to June 2022. mRNA levels of IFN-γ and IL-4 were quantified using RT-PCR, while protein expression was determined via ELISA. Results: OLP patients demonstrated significantly elevated IFN-γ and IL-4 mRNA and protein levels compared to healthy controls ( p < .05). Both erosive and non-erosive subtypes showed increased cytokine expression ( p < .05). IL-4 levels were higher in the erosive subtype ( p < .05), while IFN-γ levels showed no significant difference between subtypes ( p > .05). The IFN-γ/IL-4 ratio was significantly higher in OLP patients than in controls ( p < .05), but lower in the erosive subtype compared to the non-erosive group ( p < .05). Conclusion: Elevated IFN-γ and IL-4 expression, particularly the skewed IFN-γ/IL-4 ratio in erosive OLP, highlights the importance of Th1/Th2 imbalance in OLP pathogenesis. This warrants further investigation into cytokine-targeted therapies for this chronic condition. |
| format | Article |
| id | doaj-art-69ff9e4b1efb47b193c5d72c44779022 |
| institution | Kabale University |
| issn | 2058-7392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj-art-69ff9e4b1efb47b193c5d72c447790222025-08-20T03:45:06ZengSAGE PublishingEuropean Journal of Inflammation2058-73922025-05-012310.1177/1721727X251342431Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypesXiang ZhaoYan DuHuabing GeIntroduction: Oral lichen planus (OLP) is a chronic inflammatory disease with immune system dysregulation playing a key role in its pathogenesis. Cytokines such as IFN-γ and IL-4 are critical in modulating the Th1/Th2 balance, which is implicated in the disease’s progression. This study aimed to evaluate the expression of IFN-γ and IL-4 in the peripheral blood of OLP patients and explore differences between erosive and non-erosive subtypes. Materials and Methods: A retrospective analysis included 58 OLP patients (30 non-erosive and 28 erosive) and 58 healthy controls enrolled from June 2020 to June 2022. mRNA levels of IFN-γ and IL-4 were quantified using RT-PCR, while protein expression was determined via ELISA. Results: OLP patients demonstrated significantly elevated IFN-γ and IL-4 mRNA and protein levels compared to healthy controls ( p < .05). Both erosive and non-erosive subtypes showed increased cytokine expression ( p < .05). IL-4 levels were higher in the erosive subtype ( p < .05), while IFN-γ levels showed no significant difference between subtypes ( p > .05). The IFN-γ/IL-4 ratio was significantly higher in OLP patients than in controls ( p < .05), but lower in the erosive subtype compared to the non-erosive group ( p < .05). Conclusion: Elevated IFN-γ and IL-4 expression, particularly the skewed IFN-γ/IL-4 ratio in erosive OLP, highlights the importance of Th1/Th2 imbalance in OLP pathogenesis. This warrants further investigation into cytokine-targeted therapies for this chronic condition.https://doi.org/10.1177/1721727X251342431 |
| spellingShingle | Xiang Zhao Yan Du Huabing Ge Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes European Journal of Inflammation |
| title | Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes |
| title_full | Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes |
| title_fullStr | Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes |
| title_full_unstemmed | Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes |
| title_short | Cytokine dysregulation in oral lichen planus: Differential expression of IFN-γ and IL-4 in erosive and non-erosive subtypes |
| title_sort | cytokine dysregulation in oral lichen planus differential expression of ifn γ and il 4 in erosive and non erosive subtypes |
| url | https://doi.org/10.1177/1721727X251342431 |
| work_keys_str_mv | AT xiangzhao cytokinedysregulationinorallichenplanusdifferentialexpressionofifngandil4inerosiveandnonerosivesubtypes AT yandu cytokinedysregulationinorallichenplanusdifferentialexpressionofifngandil4inerosiveandnonerosivesubtypes AT huabingge cytokinedysregulationinorallichenplanusdifferentialexpressionofifngandil4inerosiveandnonerosivesubtypes |