The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors
The molecular mechanisms underlying adrenal and thyroid neuroendocrine tumors, including their tumorigenesis, progression, and metastasis, involve unique pathways regulating cell cycle progression. To better understand these mechanisms and pathways, extensive in-depth research on cell cycle-related...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024174889 |
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| author | Ekaterina Filipovich Ekaterina Gorodkova Anastasia Shcherbakova Walaa Asaad Sergey Popov Galina Melnichenko Natalya Mokrysheva Marina Utkina |
| author_facet | Ekaterina Filipovich Ekaterina Gorodkova Anastasia Shcherbakova Walaa Asaad Sergey Popov Galina Melnichenko Natalya Mokrysheva Marina Utkina |
| author_sort | Ekaterina Filipovich |
| collection | DOAJ |
| description | The molecular mechanisms underlying adrenal and thyroid neuroendocrine tumors, including their tumorigenesis, progression, and metastasis, involve unique pathways regulating cell cycle progression. To better understand these mechanisms and pathways, extensive in-depth research on cell cycle-related genes is necessary. This review aims to describe and interpret current single-cell RNA sequencing studies on neuroblastoma, medullary thyroid cancer, and pheochromocytoma tumors. Our review summarizes differentially expressed cell cycle-related genes with distinct functions, highlighting their potential as therapeutic targets and components of panels used to determine tumor type or aggressiveness. Although some insights have been gained, there is still limited information on these topics, and further research is required to explore the regulatory mechanisms of these tumors. |
| format | Article |
| id | doaj-art-69fc4810da154c8ca092dc12c40008ba |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-69fc4810da154c8ca092dc12c40008ba2025-01-17T04:51:20ZengElsevierHeliyon2405-84402025-01-01111e41457The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumorsEkaterina Filipovich0Ekaterina Gorodkova1Anastasia Shcherbakova2Walaa Asaad3Sergey Popov4Galina Melnichenko5Natalya Mokrysheva6Marina Utkina7Laboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaLaboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaCorresponding author.; Laboratory of General, Molecular and Population Genetics, Endocrinology Research Center, Moscow, 117292, RussiaThe molecular mechanisms underlying adrenal and thyroid neuroendocrine tumors, including their tumorigenesis, progression, and metastasis, involve unique pathways regulating cell cycle progression. To better understand these mechanisms and pathways, extensive in-depth research on cell cycle-related genes is necessary. This review aims to describe and interpret current single-cell RNA sequencing studies on neuroblastoma, medullary thyroid cancer, and pheochromocytoma tumors. Our review summarizes differentially expressed cell cycle-related genes with distinct functions, highlighting their potential as therapeutic targets and components of panels used to determine tumor type or aggressiveness. Although some insights have been gained, there is still limited information on these topics, and further research is required to explore the regulatory mechanisms of these tumors.http://www.sciencedirect.com/science/article/pii/S2405844024174889Cell cycle-related genesNeuroendocrine tumorsscRNA-seqAdrenal glandThyroid glandNeuroblastoma |
| spellingShingle | Ekaterina Filipovich Ekaterina Gorodkova Anastasia Shcherbakova Walaa Asaad Sergey Popov Galina Melnichenko Natalya Mokrysheva Marina Utkina The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors Heliyon Cell cycle-related genes Neuroendocrine tumors scRNA-seq Adrenal gland Thyroid gland Neuroblastoma |
| title | The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| title_full | The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| title_fullStr | The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| title_full_unstemmed | The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| title_short | The role of cell cycle-related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| title_sort | role of cell cycle related genes in the tumorigenesis of adrenal and thyroid neuroendocrine tumors |
| topic | Cell cycle-related genes Neuroendocrine tumors scRNA-seq Adrenal gland Thyroid gland Neuroblastoma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024174889 |
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