The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma
The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic obs...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2005-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3697 |
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| author | L. Yu. Nikitina F. I. Petrovsky I. I. Ivanchuk A. E. Sazonov |
| author_facet | L. Yu. Nikitina F. I. Petrovsky I. I. Ivanchuk A. E. Sazonov |
| author_sort | L. Yu. Nikitina |
| collection | DOAJ |
| description | The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic observation, the study of apoptosis effectors expression (Polymerase Chain Reaction). Material: 60 patients with severe BA. Results: low p53 expression and eosinophils apoptosis depression were revealed in therapy-resistant asthmatics. Conclusion: eosinophil apoptosis disregulation – the key mechanism of persistent inflammation of the airways in therapy-resistant BA. |
| format | Article |
| id | doaj-art-69faad5b1bf94635a26da2f5ec88cdd3 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2005-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-69faad5b1bf94635a26da2f5ec88cdd32025-08-20T03:01:54ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842005-12-0144647010.20538/1682-0363-2005-4-64-702336The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthmaL. Yu. Nikitina0F. I. Petrovsky1I. I. Ivanchuk2A. E. Sazonov3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic observation, the study of apoptosis effectors expression (Polymerase Chain Reaction). Material: 60 patients with severe BA. Results: low p53 expression and eosinophils apoptosis depression were revealed in therapy-resistant asthmatics. Conclusion: eosinophil apoptosis disregulation – the key mechanism of persistent inflammation of the airways in therapy-resistant BA.https://bulletin.ssmu.ru/jour/article/view/3697therapy-resistant severe asthmaeosinophilapoptosisp53bcl-2bax |
| spellingShingle | L. Yu. Nikitina F. I. Petrovsky I. I. Ivanchuk A. E. Sazonov The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma Бюллетень сибирской медицины therapy-resistant severe asthma eosinophil apoptosis p53 bcl-2 bax |
| title | The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma |
| title_full | The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma |
| title_fullStr | The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma |
| title_full_unstemmed | The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma |
| title_short | The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma |
| title_sort | peculiarities of eosinophil apoptosis damage in patients with severe therapy resistant bronchial asthma |
| topic | therapy-resistant severe asthma eosinophil apoptosis p53 bcl-2 bax |
| url | https://bulletin.ssmu.ru/jour/article/view/3697 |
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