The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases
The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed a...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/689492 |
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| author | Caroline Marcantonio Ferreira Angélica Thomaz Vieira Marco Aurelio Ramirez Vinolo Fernando A. Oliveira Rui Curi Flaviano dos Santos Martins |
| author_facet | Caroline Marcantonio Ferreira Angélica Thomaz Vieira Marco Aurelio Ramirez Vinolo Fernando A. Oliveira Rui Curi Flaviano dos Santos Martins |
| author_sort | Caroline Marcantonio Ferreira |
| collection | DOAJ |
| description | The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases. |
| format | Article |
| id | doaj-art-69f5c1feea2d4e8399b829bf693b6780 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-69f5c1feea2d4e8399b829bf693b67802025-08-20T02:23:55ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/689492689492The Central Role of the Gut Microbiota in Chronic Inflammatory DiseasesCaroline Marcantonio Ferreira0Angélica Thomaz Vieira1Marco Aurelio Ramirez Vinolo2Fernando A. Oliveira3Rui Curi4Flaviano dos Santos Martins5Department of Pharmacology, Institute of Biomedical Sciences, ICB-1, Sao Paulo University, 05508-000 São Paulo, SP, BrazilDepartment of Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, 13083-970 Campinas, SP, BrazilDepartment of Biological Sciences, Section of Physiology and Pharmacology, Federal University of Sao Paulo, 09913-030 Diadema, SP, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, ICB-1, Sao Paulo University, 05508-000 São Paulo, SP, BrazilDepartment of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilThe commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases.http://dx.doi.org/10.1155/2014/689492 |
| spellingShingle | Caroline Marcantonio Ferreira Angélica Thomaz Vieira Marco Aurelio Ramirez Vinolo Fernando A. Oliveira Rui Curi Flaviano dos Santos Martins The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases Journal of Immunology Research |
| title | The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases |
| title_full | The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases |
| title_fullStr | The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases |
| title_full_unstemmed | The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases |
| title_short | The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases |
| title_sort | central role of the gut microbiota in chronic inflammatory diseases |
| url | http://dx.doi.org/10.1155/2014/689492 |
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