An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray
The chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and so...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/940613 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560949076164608 |
|---|---|
| author | Handong Ouyang Shue Liu Weian Zeng Roy C. Levitt Keith A. Candiotti Shuanglin Hao |
| author_facet | Handong Ouyang Shue Liu Weian Zeng Roy C. Levitt Keith A. Candiotti Shuanglin Hao |
| author_sort | Handong Ouyang |
| collection | DOAJ |
| description | The chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. Among the brain regions implicated in opiate dependence and withdrawal, the periaqueductal gray area (PAG) appears to be critical in regulating the complex signs and symptoms of opioid withdrawal. Numerous neurochemical mechanisms in the PAG have been identified that may contribute to the opioid withdrawal syndrome. Accumulating evidence suggests that glial activation leading to the release of proinflammatory molecules acting on neurons is important in the complex syndrome of opioid dependence and withdrawal. This paper focuses on the recent advances in our understanding of the vital role that glia-neuron interactions play in opioid dependence and withdrawal within the PAG. We summarize those neurochemical mechanisms associated with opioid withdrawal including the recently defined importance of TNFα release from activated glial cells that communicate with TNF receptors on PAG neurons. |
| format | Article |
| id | doaj-art-69efb8557e1f4c00bdb1c6a047e3ea63 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-69efb8557e1f4c00bdb1c6a047e3ea632025-02-03T01:26:17ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/940613940613An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal GrayHandong Ouyang0Shue Liu1Weian Zeng2Roy C. Levitt3Keith A. Candiotti4Shuanglin Hao5Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USADepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USADepartment of Anesthesiology, State Key Laboratory of Oncology on Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USAThe chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. Among the brain regions implicated in opiate dependence and withdrawal, the periaqueductal gray area (PAG) appears to be critical in regulating the complex signs and symptoms of opioid withdrawal. Numerous neurochemical mechanisms in the PAG have been identified that may contribute to the opioid withdrawal syndrome. Accumulating evidence suggests that glial activation leading to the release of proinflammatory molecules acting on neurons is important in the complex syndrome of opioid dependence and withdrawal. This paper focuses on the recent advances in our understanding of the vital role that glia-neuron interactions play in opioid dependence and withdrawal within the PAG. We summarize those neurochemical mechanisms associated with opioid withdrawal including the recently defined importance of TNFα release from activated glial cells that communicate with TNF receptors on PAG neurons.http://dx.doi.org/10.1100/2012/940613 |
| spellingShingle | Handong Ouyang Shue Liu Weian Zeng Roy C. Levitt Keith A. Candiotti Shuanglin Hao An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray The Scientific World Journal |
| title | An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray |
| title_full | An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray |
| title_fullStr | An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray |
| title_full_unstemmed | An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray |
| title_short | An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray |
| title_sort | emerging new paradigm in opioid withdrawal a critical role for glia neuron signaling in the periaqueductal gray |
| url | http://dx.doi.org/10.1100/2012/940613 |
| work_keys_str_mv | AT handongouyang anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT shueliu anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT weianzeng anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT royclevitt anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT keithacandiotti anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT shuanglinhao anemergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT handongouyang emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT shueliu emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT weianzeng emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT royclevitt emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT keithacandiotti emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray AT shuanglinhao emergingnewparadigminopioidwithdrawalacriticalroleforglianeuronsignalingintheperiaqueductalgray |