Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications
Social cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, asse...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/1849794 |
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| author | Foteini Christidi Raffaella Migliaccio Hernando Santamaría-García Gabriella Santangelo Francesca Trojsi |
| author_facet | Foteini Christidi Raffaella Migliaccio Hernando Santamaría-García Gabriella Santangelo Francesca Trojsi |
| author_sort | Foteini Christidi |
| collection | DOAJ |
| description | Social cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, assessment of social cognition, mainly focusing on four key domains, such as theory of mind (ToM), emotional empathy, and social perception and behavior, has been increasingly evaluated in clinical settings, given the potential implications of impairments of these skills for therapeutic decision-making. With regard to neurodegenerative diseases (NDs), most disorders, characterized by variable disease phenotypes and progression, although similar for the unfavorable prognosis, are associated to impairments of social cognitive function, with consequent negative effects on patients’ management. Specifically, in some NDs these deficits may represent core diagnostic criteria, such as for behavioral variant frontotemporal dementia (bvFTD), or may emerge during the disease course as critical aspects, such as for Parkinson’s and Alzheimer’s diseases. On this background, we aimed to revise the most updated evidence on the neurobiological hypotheses derived from network-based approaches, clinical manifestations, and assessment tools of social cognitive dysfunctions in NDs, also prospecting potential benefits on patients’ well-being, quality of life, and outcome derived from potential therapeutic perspectives of these deficits. |
| format | Article |
| id | doaj-art-69ed765889d34875addffdccc4102ae2 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-69ed765889d34875addffdccc4102ae22025-08-20T03:34:05ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/18497941849794Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical ImplicationsFoteini Christidi0Raffaella Migliaccio1Hernando Santamaría-García2Gabriella Santangelo3Francesca Trojsi4First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GreeceINSERM U 1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et Marie Curie-Paris 6, UMRS 1127, Institut du Cerveau et de la Moelle Épinière (ICM), 75013 Paris, FrancePontificia Universidad Javeriana Bogotá, Colombia, Centro de Memoria y Cognición Intellectus Hospital Universitario San Ignacio, Bogotá, ColombiaDepartment of Psychology, University of Campania “Luigi Vanvitelli”, Caserta, ItalyDepartment of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, ItalySocial cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, assessment of social cognition, mainly focusing on four key domains, such as theory of mind (ToM), emotional empathy, and social perception and behavior, has been increasingly evaluated in clinical settings, given the potential implications of impairments of these skills for therapeutic decision-making. With regard to neurodegenerative diseases (NDs), most disorders, characterized by variable disease phenotypes and progression, although similar for the unfavorable prognosis, are associated to impairments of social cognitive function, with consequent negative effects on patients’ management. Specifically, in some NDs these deficits may represent core diagnostic criteria, such as for behavioral variant frontotemporal dementia (bvFTD), or may emerge during the disease course as critical aspects, such as for Parkinson’s and Alzheimer’s diseases. On this background, we aimed to revise the most updated evidence on the neurobiological hypotheses derived from network-based approaches, clinical manifestations, and assessment tools of social cognitive dysfunctions in NDs, also prospecting potential benefits on patients’ well-being, quality of life, and outcome derived from potential therapeutic perspectives of these deficits.http://dx.doi.org/10.1155/2018/1849794 |
| spellingShingle | Foteini Christidi Raffaella Migliaccio Hernando Santamaría-García Gabriella Santangelo Francesca Trojsi Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications Behavioural Neurology |
| title | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
| title_full | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
| title_fullStr | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
| title_full_unstemmed | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
| title_short | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
| title_sort | social cognition dysfunctions in neurodegenerative diseases neuroanatomical correlates and clinical implications |
| url | http://dx.doi.org/10.1155/2018/1849794 |
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