Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit?
<h4>Background/objectives</h4>The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic mali...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184079&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230142193893376 |
|---|---|
| author | Bruno Memória Okubo Anacélia Gomes de Matos Howard Lopes Ribeiro Junior Daniela de Paula Borges Roberta Taiane Germano de Oliveira Marilena Facundo de Castro Manoel Ricardo Alves Martins Romélia Pinheiro Gonçalves Pedro Felipe Carvalhedo Bruin Ronald Feitosa Pinheiro Silvia Maria Meira Magalhães |
| author_facet | Bruno Memória Okubo Anacélia Gomes de Matos Howard Lopes Ribeiro Junior Daniela de Paula Borges Roberta Taiane Germano de Oliveira Marilena Facundo de Castro Manoel Ricardo Alves Martins Romélia Pinheiro Gonçalves Pedro Felipe Carvalhedo Bruin Ronald Feitosa Pinheiro Silvia Maria Meira Magalhães |
| author_sort | Bruno Memória Okubo |
| collection | DOAJ |
| description | <h4>Background/objectives</h4>The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory muscle strength and lung function in elderly patients with anemia, compare data between myelodysplastic syndromes and non-clonal anemias and evaluate the influence of serum IL-8 level and NF-kB activity on deteriorate pulmonary function in this specific population.<h4>Participants</h4>Individuals aged 60 and older with anemia secondary to MDS, non-clonal anemia and healthy elderly individuals.<h4>Measurements</h4>Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/ FVC ratio were measured by spirometry. Respiratory muscle strength was evaluated by maximal static respiratory pressures measurement. IL-8 analysis was performed by ELISA and activity of NF-kB by chemiluminescent assay.<h4>Results</h4>Mean Hb concentration was comparable between patients with anemia. Significant differences were detected between all patients with anemia and controls for maximum-effort inspiratory mouth pressure (PImax) and also for maximum-effort expiratory mouth pressure (PEmax). The MDS group recorded a significantly lower PImax and PEmax percent predicted when compared to non-clonal anemia group. For FVC and FEV1, a significant difference was found in anemic patients, with even significantly lower values for FVC and FEV1 in MDS group. No significant differences were detected for PImax and PEmax and spirometry parameters when anemic patients were stratified according to the degree of anemia. A significant negative impact in FVC (% pred), PImax (% pred) and PEmax (% pred) was observed in patients with MDS and higher levels of IL-8 or increased activity of NF-kB.<h4>Conclusion</h4>A negative impact of anemia, independent of its degree, was demonstrated in respiratory muscle strength and lung function particularly in MDS. The well known elevated proinflammatory cytokines in MDS patients were proposed to play a role as was demonstrated by detrimental effect of higher IL-8 and NF-kB in pulmonary function tests in this population. |
| format | Article |
| id | doaj-art-69e77ed526a24084b52fe6547a5ce7b4 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-69e77ed526a24084b52fe6547a5ce7b42025-08-20T02:03:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018407910.1371/journal.pone.0184079Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit?Bruno Memória OkuboAnacélia Gomes de MatosHoward Lopes Ribeiro JuniorDaniela de Paula BorgesRoberta Taiane Germano de OliveiraMarilena Facundo de CastroManoel Ricardo Alves MartinsRomélia Pinheiro GonçalvesPedro Felipe Carvalhedo BruinRonald Feitosa PinheiroSilvia Maria Meira Magalhães<h4>Background/objectives</h4>The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory muscle strength and lung function in elderly patients with anemia, compare data between myelodysplastic syndromes and non-clonal anemias and evaluate the influence of serum IL-8 level and NF-kB activity on deteriorate pulmonary function in this specific population.<h4>Participants</h4>Individuals aged 60 and older with anemia secondary to MDS, non-clonal anemia and healthy elderly individuals.<h4>Measurements</h4>Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/ FVC ratio were measured by spirometry. Respiratory muscle strength was evaluated by maximal static respiratory pressures measurement. IL-8 analysis was performed by ELISA and activity of NF-kB by chemiluminescent assay.<h4>Results</h4>Mean Hb concentration was comparable between patients with anemia. Significant differences were detected between all patients with anemia and controls for maximum-effort inspiratory mouth pressure (PImax) and also for maximum-effort expiratory mouth pressure (PEmax). The MDS group recorded a significantly lower PImax and PEmax percent predicted when compared to non-clonal anemia group. For FVC and FEV1, a significant difference was found in anemic patients, with even significantly lower values for FVC and FEV1 in MDS group. No significant differences were detected for PImax and PEmax and spirometry parameters when anemic patients were stratified according to the degree of anemia. A significant negative impact in FVC (% pred), PImax (% pred) and PEmax (% pred) was observed in patients with MDS and higher levels of IL-8 or increased activity of NF-kB.<h4>Conclusion</h4>A negative impact of anemia, independent of its degree, was demonstrated in respiratory muscle strength and lung function particularly in MDS. The well known elevated proinflammatory cytokines in MDS patients were proposed to play a role as was demonstrated by detrimental effect of higher IL-8 and NF-kB in pulmonary function tests in this population.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184079&type=printable |
| spellingShingle | Bruno Memória Okubo Anacélia Gomes de Matos Howard Lopes Ribeiro Junior Daniela de Paula Borges Roberta Taiane Germano de Oliveira Marilena Facundo de Castro Manoel Ricardo Alves Martins Romélia Pinheiro Gonçalves Pedro Felipe Carvalhedo Bruin Ronald Feitosa Pinheiro Silvia Maria Meira Magalhães Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? PLoS ONE |
| title | Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? |
| title_full | Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? |
| title_fullStr | Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? |
| title_full_unstemmed | Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? |
| title_short | Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity: Is disordered inflammatory signaling the culprit? |
| title_sort | myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity is disordered inflammatory signaling the culprit |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184079&type=printable |
| work_keys_str_mv | AT brunomemoriaokubo myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT anaceliagomesdematos myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT howardlopesribeirojunior myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT danieladepaulaborges myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT robertataianegermanodeoliveira myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT marilenafacundodecastro myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT manoelricardoalvesmartins myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT romeliapinheirogoncalves myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT pedrofelipecarvalhedobruin myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT ronaldfeitosapinheiro myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit AT silviamariameiramagalhaes myelodysplasticsyndromepatientspresentmoresevererespiratorymuscleimpairmentandreducedforcedvitalcapacityisdisorderedinflammatorysignalingtheculprit |