Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia
Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering f...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2012/430141 |
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| author | E. Vandeix F. Favard N. Pichon M. Delage-Corre B. Melloni M. Clavel |
| author_facet | E. Vandeix F. Favard N. Pichon M. Delage-Corre B. Melloni M. Clavel |
| author_sort | E. Vandeix |
| collection | DOAJ |
| description | Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered. |
| format | Article |
| id | doaj-art-69e6edfc790a45e9b661309e13db6178 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-69e6edfc790a45e9b661309e13db61782025-02-03T06:07:45ZengWileyCase Reports in Pulmonology2090-68462090-68542012-01-01201210.1155/2012/430141430141Bortezomib-Induced Bronchiolitis Obliterans Organizing PneumoniaE. Vandeix0F. Favard1N. Pichon2M. Delage-Corre3B. Melloni4M. Clavel5Medical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceMedical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceMedical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceDepartment of Pathology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceDepartment of Pulmonology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceMedical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, FranceIntroduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.http://dx.doi.org/10.1155/2012/430141 |
| spellingShingle | E. Vandeix F. Favard N. Pichon M. Delage-Corre B. Melloni M. Clavel Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia Case Reports in Pulmonology |
| title | Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia |
| title_full | Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia |
| title_fullStr | Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia |
| title_full_unstemmed | Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia |
| title_short | Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia |
| title_sort | bortezomib induced bronchiolitis obliterans organizing pneumonia |
| url | http://dx.doi.org/10.1155/2012/430141 |
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