A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling
Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease affecting various body organs and systems. The diagnosis of SLE and its complications is based on evident clinical symptoms, serological marker levels, and pathological findings. Some serological markers have a low sensitivity a...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1443440/full |
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| author | Yinghong Liu Yinghong Liu Xiaojuan Yang Xiaojuan Yang |
| author_facet | Yinghong Liu Yinghong Liu Xiaojuan Yang Xiaojuan Yang |
| author_sort | Yinghong Liu |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease affecting various body organs and systems. The diagnosis of SLE and its complications is based on evident clinical symptoms, serological marker levels, and pathological findings. Some serological markers have a low sensitivity and specificity, and biopsy procedures are invasive in nature. Hence, metabolomics has emerged as a valuable tool for SLE screening and categorization. Its application has contributed significantly to identifying SLE pathogenesis, improving clinical diagnosis, and developing treatment approaches. This review provides an overview of the utilization of metabolomics in the study of SLE, focusing on advancements in understanding the disease’s pathogenesis, aiding in diagnosis, and monitoring treatment efficacy. |
| format | Article |
| id | doaj-art-69e54db988a14ea2a679faca7b17c1fc |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-69e54db988a14ea2a679faca7b17c1fc2025-08-20T02:12:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14434401443440A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profilingYinghong Liu0Yinghong Liu1Xiaojuan Yang2Xiaojuan Yang3Department of Rheumatology, Chongqing University Central Hospital, Chongqing, ChinaDepartment of Rheumatology, Chongqing Emergency Medical Center, Chongqing, ChinaDepartment of Rheumatology, Chongqing University Central Hospital, Chongqing, ChinaDepartment of Rheumatology, Chongqing Emergency Medical Center, Chongqing, ChinaSystemic lupus erythematosus (SLE) is a multifaceted autoimmune disease affecting various body organs and systems. The diagnosis of SLE and its complications is based on evident clinical symptoms, serological marker levels, and pathological findings. Some serological markers have a low sensitivity and specificity, and biopsy procedures are invasive in nature. Hence, metabolomics has emerged as a valuable tool for SLE screening and categorization. Its application has contributed significantly to identifying SLE pathogenesis, improving clinical diagnosis, and developing treatment approaches. This review provides an overview of the utilization of metabolomics in the study of SLE, focusing on advancements in understanding the disease’s pathogenesis, aiding in diagnosis, and monitoring treatment efficacy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1443440/fullsystemic lupus erythematosusmetabolomicspathogenesislipid metabolismamino acid metabolism |
| spellingShingle | Yinghong Liu Yinghong Liu Xiaojuan Yang Xiaojuan Yang A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling Frontiers in Immunology systemic lupus erythematosus metabolomics pathogenesis lipid metabolism amino acid metabolism |
| title | A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| title_full | A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| title_fullStr | A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| title_full_unstemmed | A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| title_short | A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| title_sort | review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling |
| topic | systemic lupus erythematosus metabolomics pathogenesis lipid metabolism amino acid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1443440/full |
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