Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state
Estrogen significantly impacts women’s health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics h...
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eLife Sciences Publications Ltd
2025-01-01
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| Online Access: | https://elifesciences.org/articles/101701 |
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| author | Yao Li Hui Xin Zhexun Lian Wei Zhang |
| author_facet | Yao Li Hui Xin Zhexun Lian Wei Zhang |
| author_sort | Yao Li |
| collection | DOAJ |
| description | Estrogen significantly impacts women’s health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics has been applied to study various diseases, its use in understanding postmenopausal hypertension is scarce. Therefore, an ovariectomized rat model was used to simulate postmenopausal conditions. Estrogen levels, blood pressure, and aortic tissue metabolomics were analyzed. Animal models were divided into Sham, OVX, and OVX +E groups. Serum estrogen levels, blood pressure measurements, and aortic tissue metabolomics analyses were performed using radioimmunoassay, UHPLC-Q-TOF, and bioinformatics techniques. Based on the above research content, we successfully established a correlation between low estrogen levels and postmenopausal hypertension in rats. Notable differences in blood pressure parameters and aortic tissue metabolites were observed across the experimental groups. Specifically, metabolites that were differentially expressed, particularly L-alpha-aminobutyric acid (L-AABA), showed potential as a biomarker for postmenopausal hypertension, potentially exerting a protective function through macrophage activation and vascular remodeling. Enrichment analysis revealed alterations in sugar metabolism pathways, such as the Warburg effect and glycolysis, indicating their involvement in postmenopausal hypertension. Overall, this current research provides insights into the metabolic changes associated with postmenopausal hypertension, highlighting the role of L-AABA and sugar metabolism reprogramming in aortic tissue. The findings suggest a potential link between low estrogen levels, macrophage function, and vascular remodeling in the pathogenesis of postmenopausal hypertension. Further investigations are needed to validate these findings and explore their clinical implications for postmenopausal women. |
| format | Article |
| id | doaj-art-69e51a248f3c40fab9a5562777bec59a |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj-art-69e51a248f3c40fab9a5562777bec59a2025-01-16T13:08:42ZengeLife Sciences Publications LtdeLife2050-084X2025-01-011310.7554/eLife.101701Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen stateYao Li0Hui Xin1Zhexun Lian2Wei Zhang3https://orcid.org/0000-0002-3167-0002Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Urology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaEstrogen significantly impacts women’s health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics has been applied to study various diseases, its use in understanding postmenopausal hypertension is scarce. Therefore, an ovariectomized rat model was used to simulate postmenopausal conditions. Estrogen levels, blood pressure, and aortic tissue metabolomics were analyzed. Animal models were divided into Sham, OVX, and OVX +E groups. Serum estrogen levels, blood pressure measurements, and aortic tissue metabolomics analyses were performed using radioimmunoassay, UHPLC-Q-TOF, and bioinformatics techniques. Based on the above research content, we successfully established a correlation between low estrogen levels and postmenopausal hypertension in rats. Notable differences in blood pressure parameters and aortic tissue metabolites were observed across the experimental groups. Specifically, metabolites that were differentially expressed, particularly L-alpha-aminobutyric acid (L-AABA), showed potential as a biomarker for postmenopausal hypertension, potentially exerting a protective function through macrophage activation and vascular remodeling. Enrichment analysis revealed alterations in sugar metabolism pathways, such as the Warburg effect and glycolysis, indicating their involvement in postmenopausal hypertension. Overall, this current research provides insights into the metabolic changes associated with postmenopausal hypertension, highlighting the role of L-AABA and sugar metabolism reprogramming in aortic tissue. The findings suggest a potential link between low estrogen levels, macrophage function, and vascular remodeling in the pathogenesis of postmenopausal hypertension. Further investigations are needed to validate these findings and explore their clinical implications for postmenopausal women.https://elifesciences.org/articles/101701postmenopausal hypertensioncarbohydrate metabolismvascular remodeling |
| spellingShingle | Yao Li Hui Xin Zhexun Lian Wei Zhang Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state eLife postmenopausal hypertension carbohydrate metabolism vascular remodeling |
| title | Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| title_full | Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| title_fullStr | Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| title_full_unstemmed | Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| title_short | Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| title_sort | exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state |
| topic | postmenopausal hypertension carbohydrate metabolism vascular remodeling |
| url | https://elifesciences.org/articles/101701 |
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