Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion
Background: Periprosthetic joint infections (PJIs) are a significant complication following total hip arthroplasty, impacting patient health and healthcare costs. This study examines the incidence of acute kidney injury (AKI) in patients undergoing hip PJI treatment with a combination of intravenous...
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Elsevier
2025-02-01
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| Series: | Arthroplasty Today |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352344125000032 |
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| author | Wenbo Mu, MD, PhD Boyong Xu, MD Fei Wang, MD Wentao Guo, MD, PhD Xiaogang Zhang, MD Li Cao, MD |
| author_facet | Wenbo Mu, MD, PhD Boyong Xu, MD Fei Wang, MD Wentao Guo, MD, PhD Xiaogang Zhang, MD Li Cao, MD |
| author_sort | Wenbo Mu, MD, PhD |
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| description | Background: Periprosthetic joint infections (PJIs) are a significant complication following total hip arthroplasty, impacting patient health and healthcare costs. This study examines the incidence of acute kidney injury (AKI) in patients undergoing hip PJI treatment with a combination of intravenous and intra-articular antibiotic infusion therapies. Methods: A retrospective review of 151 patient records from May 1, 2010 to December 30, 2022 was conducted at a single academic hospital. Patients were treated for hip PJIs using debridement, antibiotics, and implant retention or single-stage revision surgeries. AKI was classified according to the Kidney Disease: Improving Global Outcomes criteria. Results: Among 151 patients, 17 (11.26%) developed AKI, with 13 cases resolving transiently before discharge. The median onset of AKI was on postoperative day 2, with stage I AKI being the most prevalent, accounting for 64.71% of cases. Diabetes and low baseline serum creatinine levels were identified as independent risk factors for AKI, with odds ratios of 9.69 and 1.09, respectively. Conclusions: The combined regimen of intra-articular and intravenous antibiotic infusion appears to have a manageable risk profile regarding AKI. This approach could serve as a viable alternative for PJI management, emphasizing the importance of careful patient monitoring and tailored antibiotic regimens. Further studies are recommended to optimize treatment protocols and mitigate risks. |
| format | Article |
| id | doaj-art-69e4395dcf484cdb9c66c407a9d270f9 |
| institution | Kabale University |
| issn | 2352-3441 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arthroplasty Today |
| spelling | doaj-art-69e4395dcf484cdb9c66c407a9d270f92025-02-10T04:34:33ZengElsevierArthroplasty Today2352-34412025-02-0131101616Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic InfusionWenbo Mu, MD, PhD0Boyong Xu, MD1Fei Wang, MD2Wentao Guo, MD, PhD3Xiaogang Zhang, MD4Li Cao, MD5Department of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China; Key Laboratory of High Incidence Disease Research in Xingjiang (Xinjiang Medical University), Ministry of Education, Urumqi, Xinjiang, China; Xinjiang Clinical Research Center for Orthopedics, Urumqi, Xinjiang, China; Corresponding author. Department of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, NO. 137 South Liyushan Road, Urumqi, Xinjiang 830011, China. Tel.: +86 139 099 15960.Background: Periprosthetic joint infections (PJIs) are a significant complication following total hip arthroplasty, impacting patient health and healthcare costs. This study examines the incidence of acute kidney injury (AKI) in patients undergoing hip PJI treatment with a combination of intravenous and intra-articular antibiotic infusion therapies. Methods: A retrospective review of 151 patient records from May 1, 2010 to December 30, 2022 was conducted at a single academic hospital. Patients were treated for hip PJIs using debridement, antibiotics, and implant retention or single-stage revision surgeries. AKI was classified according to the Kidney Disease: Improving Global Outcomes criteria. Results: Among 151 patients, 17 (11.26%) developed AKI, with 13 cases resolving transiently before discharge. The median onset of AKI was on postoperative day 2, with stage I AKI being the most prevalent, accounting for 64.71% of cases. Diabetes and low baseline serum creatinine levels were identified as independent risk factors for AKI, with odds ratios of 9.69 and 1.09, respectively. Conclusions: The combined regimen of intra-articular and intravenous antibiotic infusion appears to have a manageable risk profile regarding AKI. This approach could serve as a viable alternative for PJI management, emphasizing the importance of careful patient monitoring and tailored antibiotic regimens. Further studies are recommended to optimize treatment protocols and mitigate risks.http://www.sciencedirect.com/science/article/pii/S2352344125000032Acute kidney injuryPeriprosthetic joint infectionIntra-articular antibiotic infusionIntravenous therapyHip arthroplasty |
| spellingShingle | Wenbo Mu, MD, PhD Boyong Xu, MD Fei Wang, MD Wentao Guo, MD, PhD Xiaogang Zhang, MD Li Cao, MD Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion Arthroplasty Today Acute kidney injury Periprosthetic joint infection Intra-articular antibiotic infusion Intravenous therapy Hip arthroplasty |
| title | Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion |
| title_full | Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion |
| title_fullStr | Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion |
| title_full_unstemmed | Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion |
| title_short | Exploring Acute Kidney Injury Incidence in Hip Periprosthetic Joint Infection Treatment With Combined Intravenous and Intra-articular Antibiotic Infusion |
| title_sort | exploring acute kidney injury incidence in hip periprosthetic joint infection treatment with combined intravenous and intra articular antibiotic infusion |
| topic | Acute kidney injury Periprosthetic joint infection Intra-articular antibiotic infusion Intravenous therapy Hip arthroplasty |
| url | http://www.sciencedirect.com/science/article/pii/S2352344125000032 |
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