Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility
Background Although existing studies have identified some genetic loci associated with chronic obstructive pulmonary disease (COPD) susceptibility, many variants remain to be discovered. The aim of this study was to further explore the potential relationship between IL18R1 single nucleotide polymorp...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2446690 |
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| author | Jiaoyuan Xu Meilan Xian Linhui Huang Yamei Zheng Lei Zhang Jie Zhao Jie Chen Siguang Li Lingsang Lin Yi Zhong Zehua Yang Haihong Wu Tian Xie Yipeng Ding |
| author_facet | Jiaoyuan Xu Meilan Xian Linhui Huang Yamei Zheng Lei Zhang Jie Zhao Jie Chen Siguang Li Lingsang Lin Yi Zhong Zehua Yang Haihong Wu Tian Xie Yipeng Ding |
| author_sort | Jiaoyuan Xu |
| collection | DOAJ |
| description | Background Although existing studies have identified some genetic loci associated with chronic obstructive pulmonary disease (COPD) susceptibility, many variants remain to be discovered. The aim of this study was to further explore the potential relationship between IL18R1 single nucleotide polymorphisms (SNPs) and COPD risk.Methods Nine hundred and ninety-six subjects were recruited (498 COPD cases and 498 healthy controls). Five candidate SNPs of IL18R1 were selected and genotyped using MassARRAY iPLEX platform. Logistic regression analysis was performed to assess the association of these SNPs with COPD risk. Multifactor dimensionality reduction (MDR) software was applied to calculate the interaction of SNP-SNP on COPD risk.Results IL18R1 rs9807989 (OR = 0.42, p < .001), rs3771166 (OR = 0.40, p < .001) and rs6543124 (OR = 0.44, p < .001) were associated with the reduced COPD risk, while rs2287037 (OR = 2.71, p < .001) and rs2058622 (OR = 2.06, p < .001) might be the risk-increasing factor for COPD occurrence in both the overall analysis and subgroup analysis (age, gender, drinking, and smoking). The best multi-locus model was the combination of rs2058622 and rs3771166.Conclusion Our study provided a reference and basis for investigating the association of IL18R1 polymorphisms with COPD risk. |
| format | Article |
| id | doaj-art-69e1dc9cb5664f1cbdb9a0e7540d8f67 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-69e1dc9cb5664f1cbdb9a0e7540d8f672025-01-23T16:38:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2024.2446690Identification of genetic variants of the IL18R1 gene in association with COPD susceptibilityJiaoyuan Xu0Meilan Xian1Linhui Huang2Yamei Zheng3Lei Zhang4Jie Zhao5Jie Chen6Siguang Li7Lingsang Lin8Yi Zhong9Zehua Yang10Haihong Wu11Tian Xie12Yipeng Ding13Department of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaBackground Although existing studies have identified some genetic loci associated with chronic obstructive pulmonary disease (COPD) susceptibility, many variants remain to be discovered. The aim of this study was to further explore the potential relationship between IL18R1 single nucleotide polymorphisms (SNPs) and COPD risk.Methods Nine hundred and ninety-six subjects were recruited (498 COPD cases and 498 healthy controls). Five candidate SNPs of IL18R1 were selected and genotyped using MassARRAY iPLEX platform. Logistic regression analysis was performed to assess the association of these SNPs with COPD risk. Multifactor dimensionality reduction (MDR) software was applied to calculate the interaction of SNP-SNP on COPD risk.Results IL18R1 rs9807989 (OR = 0.42, p < .001), rs3771166 (OR = 0.40, p < .001) and rs6543124 (OR = 0.44, p < .001) were associated with the reduced COPD risk, while rs2287037 (OR = 2.71, p < .001) and rs2058622 (OR = 2.06, p < .001) might be the risk-increasing factor for COPD occurrence in both the overall analysis and subgroup analysis (age, gender, drinking, and smoking). The best multi-locus model was the combination of rs2058622 and rs3771166.Conclusion Our study provided a reference and basis for investigating the association of IL18R1 polymorphisms with COPD risk.https://www.tandfonline.com/doi/10.1080/07853890.2024.2446690Chronic obstructive pulmonary diseasecase-control studyIL18R1single nucleotide polymorphisms |
| spellingShingle | Jiaoyuan Xu Meilan Xian Linhui Huang Yamei Zheng Lei Zhang Jie Zhao Jie Chen Siguang Li Lingsang Lin Yi Zhong Zehua Yang Haihong Wu Tian Xie Yipeng Ding Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility Annals of Medicine Chronic obstructive pulmonary disease case-control study IL18R1 single nucleotide polymorphisms |
| title | Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility |
| title_full | Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility |
| title_fullStr | Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility |
| title_full_unstemmed | Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility |
| title_short | Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility |
| title_sort | identification of genetic variants of the il18r1 gene in association with copd susceptibility |
| topic | Chronic obstructive pulmonary disease case-control study IL18R1 single nucleotide polymorphisms |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2446690 |
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