Bovine Adenoviral Vector-Based Platform for Vaccine Development
Adenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic. However, the widespread use of these platforms, the prevalence of various HAdV types, and the resulting preexisting immunity hav...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/5/494 |
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| author | Ekramy E. Sayedahmed Vivek Gairola Muralimanohara S. T. Murala Suresh K. Mittal |
| author_facet | Ekramy E. Sayedahmed Vivek Gairola Muralimanohara S. T. Murala Suresh K. Mittal |
| author_sort | Ekramy E. Sayedahmed |
| collection | DOAJ |
| description | Adenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic. However, the widespread use of these platforms, the prevalence of various HAdV types, and the resulting preexisting immunity have significantly impacted the vaccines utilizing these vector platforms. Considering these challenges, the bovine AdV type 3 (BAdV-3) vector system has emerged as a versatile and innovative platform for developing next-generation vaccines against infectious diseases. Inherent attributes like a high transduction efficiency, large transgene insertion capacity, broad tissue tropism, and robust induction of innate immunity add significant value to the BAdV vector platform for vaccine design. BAdV-3 vectors effectively elude HAdV-specific preexisting humoral and cellular immune responses. Additionally, BAdV-3 is low in pathogenicity for its host and is anticipated to be safe as a vaccine platform. This systematic review provides an overview of the development of BAdV-3 as a vaccine delivery platform and its application in designing vaccines for infectious agents of human and veterinary importance. |
| format | Article |
| id | doaj-art-69df10e3d1bc408ab7bbaeb4fdbdb485 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-69df10e3d1bc408ab7bbaeb4fdbdb4852025-08-20T03:48:01ZengMDPI AGVaccines2076-393X2025-05-0113549410.3390/vaccines13050494Bovine Adenoviral Vector-Based Platform for Vaccine DevelopmentEkramy E. Sayedahmed0Vivek Gairola1Muralimanohara S. T. Murala2Suresh K. Mittal3Department of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology and Infectious Disease, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907-2027, USADepartment of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology and Infectious Disease, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907-2027, USADepartment of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology and Infectious Disease, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907-2027, USADepartment of Comparative Pathobiology and Purdue Institute of Inflammation, Immunology and Infectious Disease, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907-2027, USAAdenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic. However, the widespread use of these platforms, the prevalence of various HAdV types, and the resulting preexisting immunity have significantly impacted the vaccines utilizing these vector platforms. Considering these challenges, the bovine AdV type 3 (BAdV-3) vector system has emerged as a versatile and innovative platform for developing next-generation vaccines against infectious diseases. Inherent attributes like a high transduction efficiency, large transgene insertion capacity, broad tissue tropism, and robust induction of innate immunity add significant value to the BAdV vector platform for vaccine design. BAdV-3 vectors effectively elude HAdV-specific preexisting humoral and cellular immune responses. Additionally, BAdV-3 is low in pathogenicity for its host and is anticipated to be safe as a vaccine platform. This systematic review provides an overview of the development of BAdV-3 as a vaccine delivery platform and its application in designing vaccines for infectious agents of human and veterinary importance.https://www.mdpi.com/2076-393X/13/5/494bovine adenoviruspathogenesisvirion structuregenome organizationbovine adenoviral vector-based platformnonhuman adenoviral vector system |
| spellingShingle | Ekramy E. Sayedahmed Vivek Gairola Muralimanohara S. T. Murala Suresh K. Mittal Bovine Adenoviral Vector-Based Platform for Vaccine Development Vaccines bovine adenovirus pathogenesis virion structure genome organization bovine adenoviral vector-based platform nonhuman adenoviral vector system |
| title | Bovine Adenoviral Vector-Based Platform for Vaccine Development |
| title_full | Bovine Adenoviral Vector-Based Platform for Vaccine Development |
| title_fullStr | Bovine Adenoviral Vector-Based Platform for Vaccine Development |
| title_full_unstemmed | Bovine Adenoviral Vector-Based Platform for Vaccine Development |
| title_short | Bovine Adenoviral Vector-Based Platform for Vaccine Development |
| title_sort | bovine adenoviral vector based platform for vaccine development |
| topic | bovine adenovirus pathogenesis virion structure genome organization bovine adenoviral vector-based platform nonhuman adenoviral vector system |
| url | https://www.mdpi.com/2076-393X/13/5/494 |
| work_keys_str_mv | AT ekramyesayedahmed bovineadenoviralvectorbasedplatformforvaccinedevelopment AT vivekgairola bovineadenoviralvectorbasedplatformforvaccinedevelopment AT muralimanoharastmurala bovineadenoviralvectorbasedplatformforvaccinedevelopment AT sureshkmittal bovineadenoviralvectorbasedplatformforvaccinedevelopment |