Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

ObjectiveGastric cancer (GC) remains a leading cause of cancer-related mortality, with poorly cohesive carcinoma (PCC) exhibiting rising incidence and poor therapeutic responses. In this study, we constructed a panel of patient-derived organoids of GC and used them to understand histological accurac...

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Main Authors: Yi Yin, Shuhong Zeng, Hui Zhang, Shuangshuang Wang, Fei Ke, Qiang Rui, Jinyong Zhou, Yuwen Zhuang, Weixing Shen, Jun Qian, Shenlin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
gastric cancer (GC)
patient-derived organoids
poorly cohesive carcinoma (PCC)
drug sensitivity
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1631168/full
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