Anti-interferon-α antibodies associate with disease activity and prognosis in anti-MDA5-positive dermatomyositis

Anti-interferon-α antibodies associate with disease activity and prognosis in anti-MDA5-positive dermatomyositis

Abstract Background Interferons (IFN) are implicated in the pathogenesis of anti-MDA5 dermatomyositis (anti-MDA5-DM), but the presence of anti-IFN antibodies remains unclear. This study aims to assess serum levels of anti-IFN-α antibodies in anti-MDA5-DM patients and explore their clinical associati...

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Bibliographic Details
Main Authors: Chao Sun, Hongxia Yang, Yingfang Zhang, Shiyu Wu, Xinxin Zhang, Wei Jiang, Qinglin Peng, Guochun Wang, Xin Lu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Anti-interferon-α antibody
MDA5
Dermatomyositis
Disease activity
Prognosis
Online Access:https://doi.org/10.1186/s13075-025-03600-0
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