The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease
Objective. To investigate the clinical features and potential risk factors of aneurysmal lesions in Behcet’s disease (BD). Methods. We retrospectively reviewed the clinical data of BD patients with aneurysmal lesions in our institute from 1997 to 2017 and compared them with 207 BD patients without a...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/9198506 |
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| author | Jiaxin Zhou Jing Shi Jinjing Liu Luxi Sun Lu Li Chaoran Li Xiuhua Wu Yining Wang Xinping Tian Xiaofeng Zeng Yi Liu Wenjie Zheng Yan Zhao |
| author_facet | Jiaxin Zhou Jing Shi Jinjing Liu Luxi Sun Lu Li Chaoran Li Xiuhua Wu Yining Wang Xinping Tian Xiaofeng Zeng Yi Liu Wenjie Zheng Yan Zhao |
| author_sort | Jiaxin Zhou |
| collection | DOAJ |
| description | Objective. To investigate the clinical features and potential risk factors of aneurysmal lesions in Behcet’s disease (BD). Methods. We retrospectively reviewed the clinical data of BD patients with aneurysmal lesions in our institute from 1997 to 2017 and compared them with 207 BD patients without aneurysmal lesions. The treatment and outcome of these patients were also analyzed. Results. Sixty-nine patients were included with 117 aneurysmal lesions. The average period between BD onset and diagnosis of aneurysmal lesion was 5.4±5.5 years. Thirty-three patients (47.8%) had multiple aneurysmal lesions. Ten patients developed 20 pulmonary artery aneurysms alone. For the other 97 aortic and/or peripheral artery aneurysms in 59 patients, the most commonly affected vessels were abdominal aorta (27/97, 27.8%), coronary artery (10/97, 10.3%), and superficial femoral artery (8/97, 8.2%). Multivariate analysis revealed pathergy reaction (OR=3.78 (1.70-8.41)), arterial stenosis or occlusion (OR=44.12 (11.56-168.35)), and arterial thrombosis (OR=9.27 (2.33-36.93)) as independent predictors of aneurysmal lesions in BD. With a mean follow-up of 5.5±4.0 years, 40 patients (58.0%) achieved clinical improvements, 15 patients (21.7%) relapsed, and 10 patients (14.5%) died. The respective estimated cumulative 1- and 5-year relapse-free rates were 91.3% and 76.3%, and the respective estimated 1- and 5-year survival rates were 95.0% and 87.2%. Conclusion. Aneurysmal lesions are severe complications in BD. Pathergy reaction, arterial stenosis or occlusion, and arterial thrombosis are the risk factors of aneurysmal lesions in BD. Achieving BD remission and performing surgical or interventional procedures are both important in the treatment of these patients. |
| format | Article |
| id | doaj-art-69d20d2259924815bd470202538f7152 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-69d20d2259924815bd470202538f71522025-02-03T06:14:15ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/91985069198506The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s DiseaseJiaxin Zhou0Jing Shi1Jinjing Liu2Luxi Sun3Lu Li4Chaoran Li5Xiuhua Wu6Yining Wang7Xinping Tian8Xiaofeng Zeng9Yi Liu10Wenjie Zheng11Yan Zhao12Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, West China Hospital, Sichuan University, Guoxue Xiang 37, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Deseases (NCRC-DID), The Ministry of Education Key Laboratory, Beijing, ChinaObjective. To investigate the clinical features and potential risk factors of aneurysmal lesions in Behcet’s disease (BD). Methods. We retrospectively reviewed the clinical data of BD patients with aneurysmal lesions in our institute from 1997 to 2017 and compared them with 207 BD patients without aneurysmal lesions. The treatment and outcome of these patients were also analyzed. Results. Sixty-nine patients were included with 117 aneurysmal lesions. The average period between BD onset and diagnosis of aneurysmal lesion was 5.4±5.5 years. Thirty-three patients (47.8%) had multiple aneurysmal lesions. Ten patients developed 20 pulmonary artery aneurysms alone. For the other 97 aortic and/or peripheral artery aneurysms in 59 patients, the most commonly affected vessels were abdominal aorta (27/97, 27.8%), coronary artery (10/97, 10.3%), and superficial femoral artery (8/97, 8.2%). Multivariate analysis revealed pathergy reaction (OR=3.78 (1.70-8.41)), arterial stenosis or occlusion (OR=44.12 (11.56-168.35)), and arterial thrombosis (OR=9.27 (2.33-36.93)) as independent predictors of aneurysmal lesions in BD. With a mean follow-up of 5.5±4.0 years, 40 patients (58.0%) achieved clinical improvements, 15 patients (21.7%) relapsed, and 10 patients (14.5%) died. The respective estimated cumulative 1- and 5-year relapse-free rates were 91.3% and 76.3%, and the respective estimated 1- and 5-year survival rates were 95.0% and 87.2%. Conclusion. Aneurysmal lesions are severe complications in BD. Pathergy reaction, arterial stenosis or occlusion, and arterial thrombosis are the risk factors of aneurysmal lesions in BD. Achieving BD remission and performing surgical or interventional procedures are both important in the treatment of these patients.http://dx.doi.org/10.1155/2019/9198506 |
| spellingShingle | Jiaxin Zhou Jing Shi Jinjing Liu Luxi Sun Lu Li Chaoran Li Xiuhua Wu Yining Wang Xinping Tian Xiaofeng Zeng Yi Liu Wenjie Zheng Yan Zhao The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease Journal of Immunology Research |
| title | The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease |
| title_full | The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease |
| title_fullStr | The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease |
| title_full_unstemmed | The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease |
| title_short | The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease |
| title_sort | clinical features risk factors and outcome of aneurysmal lesions in behcet s disease |
| url | http://dx.doi.org/10.1155/2019/9198506 |
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