Inhibitory activity of royal jelly on pro-inflammatory cytokine production using a novel efficient lyophilization technique
Royal jelly has been shown to effectively inhibit the production of the three cytokines associated with cytokine storm. The present study compared freeze-dried royal jelly powder produced using traditional freeze-drying (TF) and high-efficiency fast freeze-drying (HE) and investigated the inhibitory...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Applied Food Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772502225001660 |
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| Summary: | Royal jelly has been shown to effectively inhibit the production of the three cytokines associated with cytokine storm. The present study compared freeze-dried royal jelly powder produced using traditional freeze-drying (TF) and high-efficiency fast freeze-drying (HE) and investigated the inhibitory effects of royal jelly on the production of IL-1β, IL-6, and TNF-α by using the LPS-Stimulated macrophage J774.1 in prophylactic and inflammatory models. The HE technique was observed to be more effective than the traditional freeze-drying method in inhibiting the production of the three pro-inflammatory cytokines, particularly in the prophylactic model where royal jelly was added prior to the induction of inflammation. Even no difference in crude protein content, the HE method retained a greater quantity of 10-HDA, indicating that the novel technique can effectively stabilize and preserve the active ingredients of royal jelly. |
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| ISSN: | 2772-5022 |