Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

To identify genetic loci influencing bone accrual, we performed a genome-wide association scan for total-body bone mineral density (TB-BMD) variation in 2,660 children of different ethnicities. We discovered variants in 7q31.31 associated with BMD measurements, with the lowest P = 4.1 × 10(-11) obse...

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Main Authors: Carolina Medina-Gomez, John P Kemp, Karol Estrada, Joel Eriksson, Jeff Liu, Sjur Reppe, David M Evans, Denise H M Heppe, Liesbeth Vandenput, Lizbeth Herrera, Susan M Ring, Claudia J Kruithof, Nicholas J Timpson, M Carola Zillikens, Ole K Olstad, Hou-Feng Zheng, J Brent Richards, Beate St Pourcain, Albert Hofman, Vincent W V Jaddoe, George Davey Smith, Mattias Lorentzon, Kaare M Gautvik, André G Uitterlinden, Robert Brommage, Claes Ohlsson, Jonathan H Tobias, Fernando Rivadeneira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002718&type=printable
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