Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review)
Red blood cells are the most required blood transfusion products worldwide. Safety and efficacy of blood transfusion are still relevant issues. Clarification of the causes and mechanisms of post-transfusion complications requires additional research.Aim of the review is to summarize the data of clin...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2021-02-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/2015 |
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| author | V. V. Moroz E. A. Sherstyukova E. K. Kozlova V. A. Sergunova |
| author_facet | V. V. Moroz E. A. Sherstyukova E. K. Kozlova V. A. Sergunova |
| author_sort | V. V. Moroz |
| collection | DOAJ |
| description | Red blood cells are the most required blood transfusion products worldwide. Safety and efficacy of blood transfusion are still relevant issues. Clarification of the causes and mechanisms of post-transfusion complications requires additional research.Aim of the review is to summarize the data of clinical and research studies on transfusion of red blood cell suspension with various storage times.Material. We selected 76 sources from Web of Science, Scopus, and RSCI databases containing pertinent clinical and scientific research data, as well as blood transfusion guidelines.Results. We reviewed the main stages of preparation and storage of filtered red blood cells, described biochemical and structural alterations occurring during blood storage, summarized clinical data on post-transfusion complications, and analyzed clinical consequences and molecular structure abnormalities of red blood cells in relation to their storage time.Conclusion. During long-term storage, red blood cells undergo significant structural and metabolic changes. The clinical use of relatively «old» red blood cells increases the risk of post-transfusion complications. However, the pathophysiological differences between «young» and «old» erythrocytes remain unclear. Large clinical and molecular research studies may add to our understanding of the complex issues related to blood transfusion. |
| format | Article |
| id | doaj-art-69c7538c71f34debaa131d5320f6f16e |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-69c7538c71f34debaa131d5320f6f16e2025-08-20T03:35:08ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102021-02-01171698210.15360/1813-9779-2021-1-69-821780Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review)V. V. Moroz0E. A. Sherstyukova1E. K. Kozlova2V. A. Sergunova3V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Sechenov First Moscow State Medical University, Ministry of Health of RussiaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Sechenov First Moscow State Medical University, Ministry of Health of RussiaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyRed blood cells are the most required blood transfusion products worldwide. Safety and efficacy of blood transfusion are still relevant issues. Clarification of the causes and mechanisms of post-transfusion complications requires additional research.Aim of the review is to summarize the data of clinical and research studies on transfusion of red blood cell suspension with various storage times.Material. We selected 76 sources from Web of Science, Scopus, and RSCI databases containing pertinent clinical and scientific research data, as well as blood transfusion guidelines.Results. We reviewed the main stages of preparation and storage of filtered red blood cells, described biochemical and structural alterations occurring during blood storage, summarized clinical data on post-transfusion complications, and analyzed clinical consequences and molecular structure abnormalities of red blood cells in relation to their storage time.Conclusion. During long-term storage, red blood cells undergo significant structural and metabolic changes. The clinical use of relatively «old» red blood cells increases the risk of post-transfusion complications. However, the pathophysiological differences between «young» and «old» erythrocytes remain unclear. Large clinical and molecular research studies may add to our understanding of the complex issues related to blood transfusion.https://www.reanimatology.com/rmt/article/view/2015storage of packed red blood cellblood transfusionpost-transfusion complications |
| spellingShingle | V. V. Moroz E. A. Sherstyukova E. K. Kozlova V. A. Sergunova Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) Общая реаниматология storage of packed red blood cell blood transfusion post-transfusion complications |
| title | Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) |
| title_full | Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) |
| title_fullStr | Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) |
| title_full_unstemmed | Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) |
| title_short | Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review) |
| title_sort | storage time of filtered red blood cells and post transfusion complications review |
| topic | storage of packed red blood cell blood transfusion post-transfusion complications |
| url | https://www.reanimatology.com/rmt/article/view/2015 |
| work_keys_str_mv | AT vvmoroz storagetimeoffilteredredbloodcellsandposttransfusioncomplicationsreview AT easherstyukova storagetimeoffilteredredbloodcellsandposttransfusioncomplicationsreview AT ekkozlova storagetimeoffilteredredbloodcellsandposttransfusioncomplicationsreview AT vasergunova storagetimeoffilteredredbloodcellsandposttransfusioncomplicationsreview |