Iron Deficiency Anemia in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. It includes Crohn's disease (CD) and ulcerative colitis (UC). It occurs with periods of exacerbations and remissions. One of the most common complications of IBD is iron deficiency anemia (IDA). I...
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Kazimierz Wielki University
2025-04-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/59418 |
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| author | Izabela Dzikowska Joanna Wanat Aleksandra Warunek Daria Stefaniak Wojciech Homa Gabriela Gronowicz Agata Siejka Weronika Zielińska Michał Chról |
| author_facet | Izabela Dzikowska Joanna Wanat Aleksandra Warunek Daria Stefaniak Wojciech Homa Gabriela Gronowicz Agata Siejka Weronika Zielińska Michał Chról |
| author_sort | Izabela Dzikowska |
| collection | DOAJ |
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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. It includes Crohn's disease (CD) and ulcerative colitis (UC). It occurs with periods of exacerbations and remissions. One of the most common complications of IBD is iron deficiency anemia (IDA). In IBD, iron deficiency anemia (IDA) often occurs concomitantly with anemia of chronic disease, caused by chronic inflammation of the gastrointestinal tract. Disturbance of iron homeostasis in IBD results from inflammation of the intestinal mucosa, which causes increased blood loss from the gastrointestinal tract and poor iron absorption. A key role is played by hepcidin, which, by acting on ferroportin, inhibits iron absorption in the intestines, despite its deficiency. Less common causes of anemia in IBD include vitamin B12 deficiency, folate deficiency, hemolysis, drug-induced aplasia, or liver disease such as primary sclerosing cholangitis. Symptoms of iron deficiency depend on the severity and chronicity of the anemia. Anemia reduces the quality of life of patients, so diagnosis and treatment of iron deficiency anemia in IBD is essential. Regular monitoring of anemia and iron homeostasis is recommended. Tests should be performed at the time of IBD diagnosis, every 3 months in active disease and every 6-12 months in periods of remission. In all patients with IBD, it is necessary to follow an appropriate diet, but also to treat anemia with iron preparations, oral or intravenous. The choice of the method of iron administration, oral or intravenous, depends on the hemoglobin level, IBD activity, and the patient's tolerance to oral preparations. Regular monitoring is essential because anemia in IBD often recurs.
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| format | Article |
| id | doaj-art-69c73fee4f664f0f9e586ed645f69f46 |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-69c73fee4f664f0f9e586ed645f69f462025-08-20T02:17:34ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-04-018010.12775/JEHS.2025.80.59418Iron Deficiency Anemia in Inflammatory Bowel Disease Izabela Dzikowska0https://orcid.org/0009-0006-5539-3771Joanna Wanat1https://orcid.org/0009-0009-3349-3618Aleksandra Warunek2https://orcid.org/0009-0000-7542-6522Daria Stefaniak3https://orcid.org/0009-0002-2207-4177Wojciech Homa4https://orcid.org/0000-0003-2177-8818Gabriela Gronowicz5https://orcid.org/0009-0009-4034-1284Agata Siejka6https://orcid.org/0009-0009-2332-0115Weronika Zielińska7https://orcid.org/0009-0007-0707-9590Michał Chról8https://orcid.org/0009-0005-7776-6260Medical University of Lublin. Aleje Racławickie 1, 20-059 Lublin, Poland.Medical University of Lublin Aleje Racławickie 1, 20-059 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 LublinWojewódzki Szpital Specjalistyczny al. Kraśnicka 100, 20-718 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 LublinMedical University of Lublin Aleje Racławickie 1, 20-059 Lublin Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. It includes Crohn's disease (CD) and ulcerative colitis (UC). It occurs with periods of exacerbations and remissions. One of the most common complications of IBD is iron deficiency anemia (IDA). In IBD, iron deficiency anemia (IDA) often occurs concomitantly with anemia of chronic disease, caused by chronic inflammation of the gastrointestinal tract. Disturbance of iron homeostasis in IBD results from inflammation of the intestinal mucosa, which causes increased blood loss from the gastrointestinal tract and poor iron absorption. A key role is played by hepcidin, which, by acting on ferroportin, inhibits iron absorption in the intestines, despite its deficiency. Less common causes of anemia in IBD include vitamin B12 deficiency, folate deficiency, hemolysis, drug-induced aplasia, or liver disease such as primary sclerosing cholangitis. Symptoms of iron deficiency depend on the severity and chronicity of the anemia. Anemia reduces the quality of life of patients, so diagnosis and treatment of iron deficiency anemia in IBD is essential. Regular monitoring of anemia and iron homeostasis is recommended. Tests should be performed at the time of IBD diagnosis, every 3 months in active disease and every 6-12 months in periods of remission. In all patients with IBD, it is necessary to follow an appropriate diet, but also to treat anemia with iron preparations, oral or intravenous. The choice of the method of iron administration, oral or intravenous, depends on the hemoglobin level, IBD activity, and the patient's tolerance to oral preparations. Regular monitoring is essential because anemia in IBD often recurs. https://apcz.umk.pl/JEHS/article/view/59418inflammatory bowel diseaseiron deficiency anemiaCrohn's disease (CD)ulcerative colitis (UC)iron supplementationiron |
| spellingShingle | Izabela Dzikowska Joanna Wanat Aleksandra Warunek Daria Stefaniak Wojciech Homa Gabriela Gronowicz Agata Siejka Weronika Zielińska Michał Chról Iron Deficiency Anemia in Inflammatory Bowel Disease Journal of Education, Health and Sport inflammatory bowel disease iron deficiency anemia Crohn's disease (CD) ulcerative colitis (UC) iron supplementation iron |
| title | Iron Deficiency Anemia in Inflammatory Bowel Disease |
| title_full | Iron Deficiency Anemia in Inflammatory Bowel Disease |
| title_fullStr | Iron Deficiency Anemia in Inflammatory Bowel Disease |
| title_full_unstemmed | Iron Deficiency Anemia in Inflammatory Bowel Disease |
| title_short | Iron Deficiency Anemia in Inflammatory Bowel Disease |
| title_sort | iron deficiency anemia in inflammatory bowel disease |
| topic | inflammatory bowel disease iron deficiency anemia Crohn's disease (CD) ulcerative colitis (UC) iron supplementation iron |
| url | https://apcz.umk.pl/JEHS/article/view/59418 |
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