Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives

Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives

Anthracyclines have been clinically well established in cancer chemotherapy for decades. The main limitations of this drug class are the development of resistance and severe side effects. In the present investigation, we analyzed 30 anthracyclines in a panel of 59 cell lines of the National Cancer I...

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Bibliographic Details
Main Authors: Rümeysa Yücer, Rossana Piccinno, Ednah Ooko, Mona Dawood, Gerhard Bringmann, Thomas Efferth
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
anthracyclines
chemotherapy
drug development
Kaplan–Meier statistics
molecular docking
multidrug resistance
Online Access:https://www.mdpi.com/2218-273X/15/7/971
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