Plasma levels of amino acids and osteoporosis: a cross-sectional study
Abstract The role of amino acids (AAs) with bone health is still controversial. We examined the association between AAs and osteoporosis in a cross-sectional study of 135 participants aged 45 years or older from the Second Hospital of Jilin University. Plasma AAs were measured with targeted quantita...
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Nature Portfolio
2025-03-01
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| author | Shuman Yang Tong Liu Xinwei Wang Jie Lei Ann M. Vuong Xianbao Shi Qinghe Han |
| author_facet | Shuman Yang Tong Liu Xinwei Wang Jie Lei Ann M. Vuong Xianbao Shi Qinghe Han |
| author_sort | Shuman Yang |
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| description | Abstract The role of amino acids (AAs) with bone health is still controversial. We examined the association between AAs and osteoporosis in a cross-sectional study of 135 participants aged 45 years or older from the Second Hospital of Jilin University. Plasma AAs were measured with targeted quantitative methodology. We measured bone mineral density (BMD) with dual energy x-ray absorptiometry, and osteoporosis was defined as a T-score ≤ -2.5. We estimated odds ratios (OR) and corresponding 95% confidence intervals (CIs) for the associations between AAs (per 1 standard deviation increase) with osteoporosis. Approximately 18.5% of participants (n = 25) had osteoporosis. Total (adjusted β = 0.052; P = 0.002) and non-essential AA (adjusted β = 0.064; P = 0.002) levels were associated with femoral neck BMD T-scores. Greater levels of total (adjusted OR: 0.734; 95% CI: 0.655–0.821), essential (adjusted OR: 0.763; 95% CI: 0.623–0.934) and non-essential AAs (adjusted OR: 0.721; 95% CI: 0.629–0.826) were associated with lower odds of osteoporosis. Higher tryptophan (adjusted OR: 0.498; 95% CI: 0.281–0.882), cysteine (adjusted OR: 0.561; 95% CI: 0.321–0.983), glycine (adjusted OR: 0.513; 95% CI: 0.285–0.922), and ornithine levels (adjusted OR: 0.581; 95% CI: 0.345–0.978) were associated with reduced osteoporosis risk. Higher AA levels were associated with higher femoral neck BMD, and lower odds of osteoporosis. |
| format | Article |
| id | doaj-art-69bc4ddacdd5419d83ab543e5fe0086d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-69bc4ddacdd5419d83ab543e5fe0086d2025-08-20T03:41:47ZengNature PortfolioScientific Reports2045-23222025-03-011511910.1038/s41598-025-94766-9Plasma levels of amino acids and osteoporosis: a cross-sectional studyShuman Yang0Tong Liu1Xinwei Wang2Jie Lei3Ann M. Vuong4Xianbao Shi5Qinghe Han6Department of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityMagnetic resonance department, The FAW General Hospital of Jilin ProvinceDepartment of Epidemiology and Biostatistics, School of Public Health, University of NevadaDepartment of Pharmacy, The First Affiliated Hospital of Jinzhou Medical UniversityDepartment of Radiology, The Second Hospital of Jilin UniversityAbstract The role of amino acids (AAs) with bone health is still controversial. We examined the association between AAs and osteoporosis in a cross-sectional study of 135 participants aged 45 years or older from the Second Hospital of Jilin University. Plasma AAs were measured with targeted quantitative methodology. We measured bone mineral density (BMD) with dual energy x-ray absorptiometry, and osteoporosis was defined as a T-score ≤ -2.5. We estimated odds ratios (OR) and corresponding 95% confidence intervals (CIs) for the associations between AAs (per 1 standard deviation increase) with osteoporosis. Approximately 18.5% of participants (n = 25) had osteoporosis. Total (adjusted β = 0.052; P = 0.002) and non-essential AA (adjusted β = 0.064; P = 0.002) levels were associated with femoral neck BMD T-scores. Greater levels of total (adjusted OR: 0.734; 95% CI: 0.655–0.821), essential (adjusted OR: 0.763; 95% CI: 0.623–0.934) and non-essential AAs (adjusted OR: 0.721; 95% CI: 0.629–0.826) were associated with lower odds of osteoporosis. Higher tryptophan (adjusted OR: 0.498; 95% CI: 0.281–0.882), cysteine (adjusted OR: 0.561; 95% CI: 0.321–0.983), glycine (adjusted OR: 0.513; 95% CI: 0.285–0.922), and ornithine levels (adjusted OR: 0.581; 95% CI: 0.345–0.978) were associated with reduced osteoporosis risk. Higher AA levels were associated with higher femoral neck BMD, and lower odds of osteoporosis.https://doi.org/10.1038/s41598-025-94766-9Amino acidsBone mineral densityOsteopeniaOsteoporosisMetabolomics |
| spellingShingle | Shuman Yang Tong Liu Xinwei Wang Jie Lei Ann M. Vuong Xianbao Shi Qinghe Han Plasma levels of amino acids and osteoporosis: a cross-sectional study Scientific Reports Amino acids Bone mineral density Osteopenia Osteoporosis Metabolomics |
| title | Plasma levels of amino acids and osteoporosis: a cross-sectional study |
| title_full | Plasma levels of amino acids and osteoporosis: a cross-sectional study |
| title_fullStr | Plasma levels of amino acids and osteoporosis: a cross-sectional study |
| title_full_unstemmed | Plasma levels of amino acids and osteoporosis: a cross-sectional study |
| title_short | Plasma levels of amino acids and osteoporosis: a cross-sectional study |
| title_sort | plasma levels of amino acids and osteoporosis a cross sectional study |
| topic | Amino acids Bone mineral density Osteopenia Osteoporosis Metabolomics |
| url | https://doi.org/10.1038/s41598-025-94766-9 |
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