A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice
We investigated the influence of recombinant human tumour necrosis factor alpha (TNF-α) and its derivatives termed muteins III, V, VI—in which the first 3 to 7 amino acids of native TNF-α have been replaced—on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF-α prolong...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000578 |
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| Summary: | We investigated the influence of recombinant human tumour necrosis
factor alpha (TNF-α) and its derivatives termed muteins III, V,
VI—in which the first 3 to 7 amino acids of native TNF-α have been
replaced—on the survival time of mice inoculated with leukaemia
L1210 or leukaemia P338. TNF-α prolonged the survival of mice with
leukaemia L1210 but did not have any therapeutic activity in
leukaemia P388-bearing mice. Muteins-treated mice with leukaemia
P388 lived longer than animals receiving TNF-α, while those
inoculated with leukaemia L1210 did not show any significant
prolongation of life compared with the TNF-α treated group. The
results presented in this report indicate that the antileukaemic
activity of TNF-α is governed at least in part by the nature of the
N-terminal amino acids. |
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| ISSN: | 0962-9351 1466-1861 |