Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
Background Current immunotherapies still have limited successful rates among cancers. It is now recognized that T cell functional state in the tumor microenvironment (TME) is a key determinant for effective antitumor immunity and immunotherapy. In addition to exhaustion, cellular senescence in tumor...
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Main Authors: | Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang |
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Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2022-10-01
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Series: | Journal for ImmunoTherapy of Cancer |
Online Access: | https://jitc.bmj.com/content/10/10/e005020.full |
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