Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.
<h4>Background</h4>WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (...
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| _version_ | 1850231081509322752 |
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| author | Chih-Tien Chen Hsiang-Lin Lee Hui-Ling Chiou Chia-Hsuan Chou Po-Hui Wang Shun-Fa Yang Ying-Erh Chou |
| author_facet | Chih-Tien Chen Hsiang-Lin Lee Hui-Ling Chiou Chia-Hsuan Chou Po-Hui Wang Shun-Fa Yang Ying-Erh Chou |
| author_sort | Chih-Tien Chen |
| collection | DOAJ |
| description | <h4>Background</h4>WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics.<h4>Methodology/principal findings</h4>The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls.<h4>Results</h4>The patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers. Furthermore, individuals who carried WISP1 rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on HCC development (AOR = 26.590, 95% CI = 9.780-72.295).<h4>Conclusions</h4>Our results demonstrated that the HCC patients with WISP1 SNPs are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC. |
| format | Article |
| id | doaj-art-69b9bcc6e0104a54ab0dcaff8971d07f |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-69b9bcc6e0104a54ab0dcaff8971d07f2025-08-20T02:03:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019896710.1371/journal.pone.0198967Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.Chih-Tien ChenHsiang-Lin LeeHui-Ling ChiouChia-Hsuan ChouPo-Hui WangShun-Fa YangYing-Erh Chou<h4>Background</h4>WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics.<h4>Methodology/principal findings</h4>The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls.<h4>Results</h4>The patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers. Furthermore, individuals who carried WISP1 rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on HCC development (AOR = 26.590, 95% CI = 9.780-72.295).<h4>Conclusions</h4>Our results demonstrated that the HCC patients with WISP1 SNPs are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC.https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198967/1/pone.0198967.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T050345Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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 |
| spellingShingle | Chih-Tien Chen Hsiang-Lin Lee Hui-Ling Chiou Chia-Hsuan Chou Po-Hui Wang Shun-Fa Yang Ying-Erh Chou Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. PLoS ONE |
| title | Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. |
| title_full | Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. |
| title_fullStr | Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. |
| title_full_unstemmed | Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. |
| title_short | Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development. |
| title_sort | impacts of wnt1 inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development |
| url | https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198967/1/pone.0198967.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T050345Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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 |
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