Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis
Objectives: To investigate the relationship between acro-osteolysis (AO), bone mineral density (BMD) and peripheral vascularity in premenopausal female patients with diffuse systemic sclerosis (dcSSc). Methods: An observational cohort study that included thirty premenopausal female patients with dcS...
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| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=1;spage=32;epage=38;aulast=Zaghlol |
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| author | Rabab S Zaghlol Sahar S Khalil Rania M Almolla Ahmed Mohamed El-Maghraby Wafaa K Makarm |
| author_facet | Rabab S Zaghlol Sahar S Khalil Rania M Almolla Ahmed Mohamed El-Maghraby Wafaa K Makarm |
| author_sort | Rabab S Zaghlol |
| collection | DOAJ |
| description | Objectives: To investigate the relationship between acro-osteolysis (AO), bone mineral density (BMD) and peripheral vascularity in premenopausal female patients with diffuse systemic sclerosis (dcSSc).
Methods: An observational cohort study that included thirty premenopausal female patients with dcSSc. The recruited patients were categorized into two groups according to the presence of radiological signs of AO. Patients were assessed clinically, laboratory and radiologically by X-ray imaging of both hands and wrists, dual-energy X-ray absorptiometry for measuring BMD and Doppler ultrasonography for evaluation of upper limbs peripheral vascularity.
Results: Overall, 80% patients had AO; comparing patients with and without AO, the former had significant increase in the frequencies of Raynaud's phenomenon, calcinosis and digital pits (88.5, 94.7, 91.7) versus (11.5, 5.3, 8.3) in the latter, respectively. Additionally, they had significantly lower distal radius BMD and higher macrovascular abnormalities at both radial and ulnar arteries ( P < 0.05). On regression analysis, the most important factors associated with AO were calcinosis (OR= 1.7; 95% CI: 1.01- 3.02; P = 0.02), Raynaud's phenomenon (OR= 3.5; 95% CI: 0.6-19.4; P = 0.003), digital pits (OR= 2.8; 95% CI: 0.9-8.8; P = 0.001), low BMD at the distal radius (OR= 1.9; 95% CI: 1.1-3.0; P = 0.002), and macrovascular changes at radial and ulnar arteries (OR = 2.2; 95% CI: 0.7-6.5; P = 0.04 and OR =1.6; 95% CI: 0.9-3.0; P = 0.05) respectively.
Conclusion: Calcinosis, Raynaud's phenomenon, digital pits, vascular alterations at radial and ulnar arteries, and low BMD at the distal radius are the most important factors associated with AO in dcSSc patients. |
| format | Article |
| id | doaj-art-69b7925bae7d4251bcfe68d15fa193bf |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-69b7925bae7d4251bcfe68d15fa193bf2025-02-03T10:54:59ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-01151323810.4103/injr.injr_144_19Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosisRabab S ZaghlolSahar S KhalilRania M AlmollaAhmed Mohamed El-MaghrabyWafaa K MakarmObjectives: To investigate the relationship between acro-osteolysis (AO), bone mineral density (BMD) and peripheral vascularity in premenopausal female patients with diffuse systemic sclerosis (dcSSc). Methods: An observational cohort study that included thirty premenopausal female patients with dcSSc. The recruited patients were categorized into two groups according to the presence of radiological signs of AO. Patients were assessed clinically, laboratory and radiologically by X-ray imaging of both hands and wrists, dual-energy X-ray absorptiometry for measuring BMD and Doppler ultrasonography for evaluation of upper limbs peripheral vascularity. Results: Overall, 80% patients had AO; comparing patients with and without AO, the former had significant increase in the frequencies of Raynaud's phenomenon, calcinosis and digital pits (88.5, 94.7, 91.7) versus (11.5, 5.3, 8.3) in the latter, respectively. Additionally, they had significantly lower distal radius BMD and higher macrovascular abnormalities at both radial and ulnar arteries ( P < 0.05). On regression analysis, the most important factors associated with AO were calcinosis (OR= 1.7; 95% CI: 1.01- 3.02; P = 0.02), Raynaud's phenomenon (OR= 3.5; 95% CI: 0.6-19.4; P = 0.003), digital pits (OR= 2.8; 95% CI: 0.9-8.8; P = 0.001), low BMD at the distal radius (OR= 1.9; 95% CI: 1.1-3.0; P = 0.002), and macrovascular changes at radial and ulnar arteries (OR = 2.2; 95% CI: 0.7-6.5; P = 0.04 and OR =1.6; 95% CI: 0.9-3.0; P = 0.05) respectively. Conclusion: Calcinosis, Raynaud's phenomenon, digital pits, vascular alterations at radial and ulnar arteries, and low BMD at the distal radius are the most important factors associated with AO in dcSSc patients.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=1;spage=32;epage=38;aulast=Zaghlolacro-osteolysisbone mineral densitysystemic sclerosisvascular changes |
| spellingShingle | Rabab S Zaghlol Sahar S Khalil Rania M Almolla Ahmed Mohamed El-Maghraby Wafaa K Makarm Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis Indian Journal of Rheumatology acro-osteolysis bone mineral density systemic sclerosis vascular changes |
| title | Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| title_full | Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| title_fullStr | Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| title_full_unstemmed | Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| title_short | Acro-osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| title_sort | acro osteolysis and its relationship with bone mineral density and peripheral vascularity in premenopausal females with systemic sclerosis |
| topic | acro-osteolysis bone mineral density systemic sclerosis vascular changes |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=1;spage=32;epage=38;aulast=Zaghlol |
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