Evaluation of Serum Interleukin-17, Transforming Growth Factor-beta Levels in Brucellosis Patients Before and After Treatment
Introduction: Brucellosis is a zoonotic disease in humans and animals and is a worldwide public health problem. Changes in inflammatory cytokines levels might be deployed as markers for diagnosing infectious diseases from noninfectious medical conditions. This study aimed to evaluate the relation...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2022-12-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://jommid.pasteur.ac.ir/article-1-424-en.html |
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| Summary: | Introduction: Brucellosis is a zoonotic disease in humans and animals and is a
worldwide public health problem. Changes in inflammatory cytokines levels
might be deployed as markers for diagnosing infectious diseases from noninfectious
medical conditions. This study aimed to evaluate the relationship
between serum levels of interleukin-17 (IL-17) and transforming growth factorbeta
(TGF-β) in pediatric brucellosis. Methods: The present case-control study
included 40 brucellosis patients and 40 matched healthy controls. Serum levels
of inflammatory cytokines were measured by ELISA, and the independent
student t-test was used to compare the levels in the brucellosis and healthy
group. Serum cytokine levels before and after treatment were compared by the
paired samples t-test. Results: The serum TGF-β level was significantly lower
in the patients compared to the control group (90.21 ± 24.44 vs. 125.63 ± 23.28
pg/mL, P<0.nv001), and the serum interleukin-17 level was significantly higher
in the case group (83.74 ± 23.57 vs. 25.95 ± 17.80 pg/ml, P<0.001). After
treatment, serum IL-17 levels significantly decreased in the case group.
Conclusion: In brucellosis patients, the serum IL-17 levels decreased
significantly, whereas TGF-β increased significantly in these patients. Hence,
the serum levels of these inflammatory cytokines can be indicators for
diagnosing pediatric brucellosis. |
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| ISSN: | 2345-5349 2345-5330 |