Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings

Improving patient survival and quality of life in chronic diseases requires prolonged and often lifelong medication intake. Less than half of patients with chronic diseases globally are adherent to their prescribed medications which preclude the full benefit of treatment, worsens therapeutic outcome...

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Main Authors: Saurav Basu, Suneela Garg, Nandini Sharma, M Meghachandra Singh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Tzu Chi Medical Journal
Subjects:
Online Access:http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=73;epage=80;aulast=Basu
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author Saurav Basu
Suneela Garg
Nandini Sharma
M Meghachandra Singh
author_facet Saurav Basu
Suneela Garg
Nandini Sharma
M Meghachandra Singh
author_sort Saurav Basu
collection DOAJ
description Improving patient survival and quality of life in chronic diseases requires prolonged and often lifelong medication intake. Less than half of patients with chronic diseases globally are adherent to their prescribed medications which preclude the full benefit of treatment, worsens therapeutic outcomes, accelerates disease progression, and causes enormous economic losses. The accurate assessment of medication adherence is pivotal for both researchers and clinicians. Medication adherence can be assessed through both direct and indirect measures. Indirect measures include both subjective (self-report measures such as questionnaire and interview) and objective (pill count and secondary database analysis) measures and constitute the mainstay of assessing medication adherence. However, the lack of an inexpensive, ubiquitous, universal gold standard for assessment of medication adherence emphasizes the need to utilize a combination of measures to differentiate adherent and nonadherent patients. The global heterogeneity in health systems precludes the development of a universal guideline for evaluating medication adherence. Methods based on the secondary database analysis are mostly ineffectual in low-resource settings lacking electronic pharmacy and insurance databases and allowing refills without updated, valid prescriptions from private pharmacies. This significantly restricts the choices for assessing adherence until digitization of medical data takes root in much of the developing world. Nevertheless, there is ample scope for improving self-report measures of adherence. Effective interview techniques, especially accounting for suboptimal patient health literacy, validation of adherence questionnaires, and avoiding conceptual fallacies in reporting adherence can improve the assessment of medication adherence and promote understanding of its causal factors.
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spelling doaj-art-69a8ef57a4524d8eadc2ee506ff0d29a2025-08-20T01:57:35ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562019-01-01312738010.4103/tcmj.tcmj_177_18Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settingsSaurav BasuSuneela GargNandini SharmaM Meghachandra SinghImproving patient survival and quality of life in chronic diseases requires prolonged and often lifelong medication intake. Less than half of patients with chronic diseases globally are adherent to their prescribed medications which preclude the full benefit of treatment, worsens therapeutic outcomes, accelerates disease progression, and causes enormous economic losses. The accurate assessment of medication adherence is pivotal for both researchers and clinicians. Medication adherence can be assessed through both direct and indirect measures. Indirect measures include both subjective (self-report measures such as questionnaire and interview) and objective (pill count and secondary database analysis) measures and constitute the mainstay of assessing medication adherence. However, the lack of an inexpensive, ubiquitous, universal gold standard for assessment of medication adherence emphasizes the need to utilize a combination of measures to differentiate adherent and nonadherent patients. The global heterogeneity in health systems precludes the development of a universal guideline for evaluating medication adherence. Methods based on the secondary database analysis are mostly ineffectual in low-resource settings lacking electronic pharmacy and insurance databases and allowing refills without updated, valid prescriptions from private pharmacies. This significantly restricts the choices for assessing adherence until digitization of medical data takes root in much of the developing world. Nevertheless, there is ample scope for improving self-report measures of adherence. Effective interview techniques, especially accounting for suboptimal patient health literacy, validation of adherence questionnaires, and avoiding conceptual fallacies in reporting adherence can improve the assessment of medication adherence and promote understanding of its causal factors.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=73;epage=80;aulast=BasuAssessmentDiabetesHypertensionLow-resource settingsMedication adherence
spellingShingle Saurav Basu
Suneela Garg
Nandini Sharma
M Meghachandra Singh
Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
Tzu Chi Medical Journal
Assessment
Diabetes
Hypertension
Low-resource settings
Medication adherence
title Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
title_full Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
title_fullStr Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
title_full_unstemmed Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
title_short Improving the assessment of medication adherence: Challenges and considerations with a focus on low-resource settings
title_sort improving the assessment of medication adherence challenges and considerations with a focus on low resource settings
topic Assessment
Diabetes
Hypertension
Low-resource settings
Medication adherence
url http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=2;spage=73;epage=80;aulast=Basu
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