Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8
Background This study aims to explore the value of anti-Müllerian hormone (AMH) in combination with angiopoietin-like protein 8 (ANGPTL8) in evaluating the ovarian function of infertile patients.Methods A total of 213 infertile patients who sought treatment in our hospital from January 2023 to July...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2530568 |
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| author | Chongbo Du Na Wang Xiaowen Ma Yanping Feng Fang Liu Yandong Deng Xiaopu Xie Yuxiao Zhang |
| author_facet | Chongbo Du Na Wang Xiaowen Ma Yanping Feng Fang Liu Yandong Deng Xiaopu Xie Yuxiao Zhang |
| author_sort | Chongbo Du |
| collection | DOAJ |
| description | Background This study aims to explore the value of anti-Müllerian hormone (AMH) in combination with angiopoietin-like protein 8 (ANGPTL8) in evaluating the ovarian function of infertile patients.Methods A total of 213 infertile patients who sought treatment in our hospital from January 2023 to July 2024 were included. Transvaginal color Doppler ultrasound assessed antral follicle count and ovarian reserve. Patients were divided into a0 control group (116 cases with normal ovarian reserve) and a research group (97 cases with decreased ovarian reserve). Serum levels of AMH, ANGPTL8, and sex hormones were measured for all patients, and results were compared between groups to analyze the combined assessment’s value.Results In the control group, AMH levels were (4.44±2.36) ng/ml, ANGPTL8 (17.81±7.79) ng/ml, and estradiol (E2) (37.21±17.78) pg/ml. In the research group, AMH was (0.64±0.61) ng/ml, ANGPTL8 (12.04±5.04) ng/ml, and E2 (32.80±10.10) pg/ml. The research group showed significantly lower AMH, ANGPTL8, and E2 levels (P<0.05) and higher FSH and LH levels (P<0.001). The combined AMH and ANGPTL8 assessment demonstrated a sensitivity of 94.0%, specificity of 95.9%, and an area under the curve of 0.988.Conclusion The combined assessment of AMH and ANGPTL8 holds significant value in evaluating ovarian function in infertile patients. |
| format | Article |
| id | doaj-art-69a70ed25b7146679cd8c81ec9a08dbe |
| institution | DOAJ |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-69a70ed25b7146679cd8c81ec9a08dbe2025-08-20T03:04:06ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2530568Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8Chongbo Du0Na Wang1Xiaowen Ma2Yanping Feng3Fang Liu4Yandong Deng5Xiaopu Xie6Yuxiao Zhang7Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Reproductive Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Reproductive Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaBackground This study aims to explore the value of anti-Müllerian hormone (AMH) in combination with angiopoietin-like protein 8 (ANGPTL8) in evaluating the ovarian function of infertile patients.Methods A total of 213 infertile patients who sought treatment in our hospital from January 2023 to July 2024 were included. Transvaginal color Doppler ultrasound assessed antral follicle count and ovarian reserve. Patients were divided into a0 control group (116 cases with normal ovarian reserve) and a research group (97 cases with decreased ovarian reserve). Serum levels of AMH, ANGPTL8, and sex hormones were measured for all patients, and results were compared between groups to analyze the combined assessment’s value.Results In the control group, AMH levels were (4.44±2.36) ng/ml, ANGPTL8 (17.81±7.79) ng/ml, and estradiol (E2) (37.21±17.78) pg/ml. In the research group, AMH was (0.64±0.61) ng/ml, ANGPTL8 (12.04±5.04) ng/ml, and E2 (32.80±10.10) pg/ml. The research group showed significantly lower AMH, ANGPTL8, and E2 levels (P<0.05) and higher FSH and LH levels (P<0.001). The combined AMH and ANGPTL8 assessment demonstrated a sensitivity of 94.0%, specificity of 95.9%, and an area under the curve of 0.988.Conclusion The combined assessment of AMH and ANGPTL8 holds significant value in evaluating ovarian function in infertile patients.https://www.tandfonline.com/doi/10.1080/09513590.2025.2530568Anti‑Müllerian HormoneAngiopoietin‑like Protein 8InfertilityOvarian Reserve FunctionDiagnostic Utility |
| spellingShingle | Chongbo Du Na Wang Xiaowen Ma Yanping Feng Fang Liu Yandong Deng Xiaopu Xie Yuxiao Zhang Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 Gynecological Endocrinology Anti‑Müllerian Hormone Angiopoietin‑like Protein 8 Infertility Ovarian Reserve Function Diagnostic Utility |
| title | Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 |
| title_full | Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 |
| title_fullStr | Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 |
| title_full_unstemmed | Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 |
| title_short | Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8 |
| title_sort | evaluating ovarian function in infertile patients the combined diagnostic utility of anti mullerian hormone and angiopoietin like protein 8 |
| topic | Anti‑Müllerian Hormone Angiopoietin‑like Protein 8 Infertility Ovarian Reserve Function Diagnostic Utility |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2530568 |
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