ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION
Background. Blood transfusion is a therapeutic choice for thalassemia with anemia. Hemosiderosis is the side effects of blood transfusions which cause impaired liver function, leads to low vitamin D levels in plasma. The low level of vitamin D cause delay in physical growth. The aim is to determine...
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Faculty of Medicine, Universitas Diponegoro
2020-11-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/29325 |
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| author | Najma Khairani Harahap Mulyono Mulyono Yetty Movieta Nency Nyoman Suci Widyastiti |
| author_facet | Najma Khairani Harahap Mulyono Mulyono Yetty Movieta Nency Nyoman Suci Widyastiti |
| author_sort | Najma Khairani Harahap |
| collection | DOAJ |
| description | Background. Blood transfusion is a therapeutic choice for thalassemia with anemia. Hemosiderosis is the side effects of blood transfusions which cause impaired liver function, leads to low vitamin D levels in plasma. The low level of vitamin D cause delay in physical growth. The aim is to determine the relation between 25-hydroxyvitamin D levels and growth parameters in thalassemia with repeated blood transfusion history. Method. In this analytical cross-sectional study, thalassemia patients with repeated blood transfusion and ages 0-18 years old were recruited. This research was held in Semarang, Purwodadi, and Rembang from May to September 2019. Thalassemia patients who met the criteria were measured the 25-hydroxyvitamin D level, physical activity and the growth parameters (weight, height, and body mass index). Results. Forty thalassemia patients aged 6-18 years old were recruited in this study. The percentage of boys are 47.5% and girls are 52.5%. Most of subject had high ferritin serum (87.5%) and low vitamin D level (87.5%). Growth parameters from the patients were 52.5% weight-for-age <5 percentile, 45% height-for-age <5 percentile and 25% BMI-for-age underweight. There isn’t significant result in 25-hydroxyvitamin D with growth parameters, and a significant result between physical activity and height-for-age (p=0.027), but not with weight-for-age and BMI-for-age. Conclusion. The 25-hydroxyvitamin D do not associate with growth parameters significantly in thalassemia with repeated blood transfusion but physical activity has significant association with height-for-age. |
| format | Article |
| id | doaj-art-69a628cdbe7043d59a22d4bd79b5460e |
| institution | Kabale University |
| issn | 2540-8844 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
| record_format | Article |
| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-69a628cdbe7043d59a22d4bd79b5460e2025-08-20T03:30:24ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442020-11-019642242810.14710/dmj.v9i6.2932525346ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSIONNajma Khairani HarahapMulyono MulyonoYetty Movieta NencyNyoman Suci WidyastitiBackground. Blood transfusion is a therapeutic choice for thalassemia with anemia. Hemosiderosis is the side effects of blood transfusions which cause impaired liver function, leads to low vitamin D levels in plasma. The low level of vitamin D cause delay in physical growth. The aim is to determine the relation between 25-hydroxyvitamin D levels and growth parameters in thalassemia with repeated blood transfusion history. Method. In this analytical cross-sectional study, thalassemia patients with repeated blood transfusion and ages 0-18 years old were recruited. This research was held in Semarang, Purwodadi, and Rembang from May to September 2019. Thalassemia patients who met the criteria were measured the 25-hydroxyvitamin D level, physical activity and the growth parameters (weight, height, and body mass index). Results. Forty thalassemia patients aged 6-18 years old were recruited in this study. The percentage of boys are 47.5% and girls are 52.5%. Most of subject had high ferritin serum (87.5%) and low vitamin D level (87.5%). Growth parameters from the patients were 52.5% weight-for-age <5 percentile, 45% height-for-age <5 percentile and 25% BMI-for-age underweight. There isn’t significant result in 25-hydroxyvitamin D with growth parameters, and a significant result between physical activity and height-for-age (p=0.027), but not with weight-for-age and BMI-for-age. Conclusion. The 25-hydroxyvitamin D do not associate with growth parameters significantly in thalassemia with repeated blood transfusion but physical activity has significant association with height-for-age.https://ejournal3.undip.ac.id/index.php/medico/article/view/29325thalassemia, 25-hydroxyvitamin d, growth parameters, physical activity |
| spellingShingle | Najma Khairani Harahap Mulyono Mulyono Yetty Movieta Nency Nyoman Suci Widyastiti ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION Jurnal Kedokteran Diponegoro thalassemia, 25-hydroxyvitamin d, growth parameters, physical activity |
| title | ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION |
| title_full | ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION |
| title_fullStr | ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION |
| title_full_unstemmed | ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION |
| title_short | ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION |
| title_sort | association between 25 hydroxyvitamin d levels and growth parameters in thalassemia with repeated blood transfusion |
| topic | thalassemia, 25-hydroxyvitamin d, growth parameters, physical activity |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/29325 |
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