The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response

Abstract The platinum-based compounds are widely used in treating various types of cancer through their heavy metal component platinum. However, the development of chemoresistance often limits their clinical effectiveness. In this study, we report the roles of heavy metal response and its associated...

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Bibliographic Details
Main Authors: Hui Chen, Yue Xu, Dingshan Chen, Di Xiao, Bing Yang, Wenqi Wang, Han Han
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
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Online Access:https://doi.org/10.1186/s12885-025-13661-8
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