Precise amplification-free detection of highly structured RNA with an enhanced SCas12a assay

Precise amplification-free detection of highly structured RNA with an enhanced SCas12a assay

Abstract The CRISPR/Cas12a system has revolutionized molecular diagnostics, yet the direct detection of RNA, particularly those with complex structures, remains a significant challenge. Here, we present an updated SCas12a system, termed SCas12aV2, which enables precise, amplification-free detection...

Full description

Saved in:
Bibliographic Details
Main Authors: Junqi Zhang, Wenhao Yin, Qingyuan Jiang, Wuxiang Mao, Wenwen Deng, Shuqi Jin, Xinping Wang, Ruyi He, Jie Qiao, Yi Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07806-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items