Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics
Clinical and immunological parameters in the children with perinatal HIV infection were investigated in the dynamics of the longterm prospective observation. It was revealed, that all the HIV infected children had clinical signs of immunodeficiency and laboratory signs of combined damage of the immu...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/379 |
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| author | A. G. Petrova E. V. Moskaleva S. V. Smirnova M. G. Evseeva S. N. Shugaeva M. G. Romantsov |
| author_facet | A. G. Petrova E. V. Moskaleva S. V. Smirnova M. G. Evseeva S. N. Shugaeva M. G. Romantsov |
| author_sort | A. G. Petrova |
| collection | DOAJ |
| description | Clinical and immunological parameters in the children with perinatal HIV infection were investigated in the dynamics of the longterm prospective observation. It was revealed, that all the HIV infected children had clinical signs of immunodeficiency and laboratory signs of combined damage of the immune system. The complex of therapeutic measures, including antiretroviral therapy, prevention of opportunistic and acute respiratory infections, rational immunotherapy to stimulate production of endogenous interferon and normalization of the balance of cytokines significantly reduced the frequency of the clinical manifestations of the infectious syndrome and improved the patients resistance to infections. |
| format | Article |
| id | doaj-art-699fbe3ece83456d863d2f2240867e10 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-699fbe3ece83456d863d2f2240867e102025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01565-65463378Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment DynamicsA. G. Petrova0E. V. Moskaleva1S. V. Smirnova2M. G. Evseeva3S. N. Shugaeva4M. G. Romantsov5Irkutsk State Medical UniversityIrkutsk State Medical UniversityResearch Institute for Medical Problems of the North, Siberian Branch of the Russian Academy of Medical Sciences, KrasnoyarskIrkutsk State Medical UniversityIrkutsk State Medical UniversityScientific and Technological Pharmaceutical Co. POLYSAN, St.PetersburgClinical and immunological parameters in the children with perinatal HIV infection were investigated in the dynamics of the longterm prospective observation. It was revealed, that all the HIV infected children had clinical signs of immunodeficiency and laboratory signs of combined damage of the immune system. The complex of therapeutic measures, including antiretroviral therapy, prevention of opportunistic and acute respiratory infections, rational immunotherapy to stimulate production of endogenous interferon and normalization of the balance of cytokines significantly reduced the frequency of the clinical manifestations of the infectious syndrome and improved the patients resistance to infections.https://www.antibiotics-chemotherapy.ru/jour/article/view/379hiv infectionchildrenimmune systemmeglumine acridone acetate |
| spellingShingle | A. G. Petrova E. V. Moskaleva S. V. Smirnova M. G. Evseeva S. N. Shugaeva M. G. Romantsov Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics Антибиотики и Химиотерапия hiv infection children immune system meglumine acridone acetate |
| title | Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics |
| title_full | Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics |
| title_fullStr | Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics |
| title_full_unstemmed | Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics |
| title_short | Manifestations of Immune Deficiency in Children with Perinatal HIV Infection in the Treatment Dynamics |
| title_sort | manifestations of immune deficiency in children with perinatal hiv infection in the treatment dynamics |
| topic | hiv infection children immune system meglumine acridone acetate |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/379 |
| work_keys_str_mv | AT agpetrova manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics AT evmoskaleva manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics AT svsmirnova manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics AT mgevseeva manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics AT snshugaeva manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics AT mgromantsov manifestationsofimmunedeficiencyinchildrenwithperinatalhivinfectioninthetreatmentdynamics |