Cholangiopathy with Respect to Biliary Innate Immunity
Biliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease. Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal role in the innate immune response. Tolerance to bacterial PAMP...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/793569 |
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| _version_ | 1849415382758064128 |
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| author | Kenichi Harada Yasuni Nakanuma |
| author_facet | Kenichi Harada Yasuni Nakanuma |
| author_sort | Kenichi Harada |
| collection | DOAJ |
| description | Biliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease. Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal role in the innate immune response. Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found. Moreover, in primary biliary cirrhosis (PBC) and biliary atresia, biliary innate immunity is closely associated with the dysregulation of the periductal cytokine milieu and the induction of biliary apoptosis and epithelial-mesenchymal transition (EMT), forming in disease-specific cholangiopathy. Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems. |
| format | Article |
| id | doaj-art-699b315572a74b769e044b0716cb07ee |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-699b315572a74b769e044b0716cb07ee2025-08-20T03:33:32ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/793569793569Cholangiopathy with Respect to Biliary Innate ImmunityKenichi Harada0Yasuni Nakanuma1Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, JapanDepartment of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, JapanBiliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease. Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal role in the innate immune response. Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found. Moreover, in primary biliary cirrhosis (PBC) and biliary atresia, biliary innate immunity is closely associated with the dysregulation of the periductal cytokine milieu and the induction of biliary apoptosis and epithelial-mesenchymal transition (EMT), forming in disease-specific cholangiopathy. Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems.http://dx.doi.org/10.1155/2012/793569 |
| spellingShingle | Kenichi Harada Yasuni Nakanuma Cholangiopathy with Respect to Biliary Innate Immunity International Journal of Hepatology |
| title | Cholangiopathy with Respect to Biliary Innate Immunity |
| title_full | Cholangiopathy with Respect to Biliary Innate Immunity |
| title_fullStr | Cholangiopathy with Respect to Biliary Innate Immunity |
| title_full_unstemmed | Cholangiopathy with Respect to Biliary Innate Immunity |
| title_short | Cholangiopathy with Respect to Biliary Innate Immunity |
| title_sort | cholangiopathy with respect to biliary innate immunity |
| url | http://dx.doi.org/10.1155/2012/793569 |
| work_keys_str_mv | AT kenichiharada cholangiopathywithrespecttobiliaryinnateimmunity AT yasuninakanuma cholangiopathywithrespecttobiliaryinnateimmunity |