Retrospective Analyzes of Extrapulmonary Tuberculosis Cases
AIM: To analyze demographic and clinical characteristics of extrapulmonary tuberculosis(EPTB) cases retrospectively. BACKGROUND: EPTB may affect all organs also the lungs and presents with a wide range of symptoms, making diagnosis challenging. METHOD: A retrospective analysis was conducted on adult...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003709 |
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| Summary: | AIM: To analyze demographic and clinical characteristics of extrapulmonary tuberculosis(EPTB) cases retrospectively. BACKGROUND: EPTB may affect all organs also the lungs and presents with a wide range of symptoms, making diagnosis challenging. METHOD: A retrospective analysis was conducted on adult EPTB-diagnosed patients at Bezmialem Vakıf University from 2013 to 2024. Data on patient demographics, clinical presentations, diagnostic methods, and outcomes were analyzed. RESULTS: Among 249 patients, 89(35.7%) were male, and 160(64.3%) were female. The mean age of male patients was 44.1±19.8 years, while female patients had a mean age of 45.9±15.8 years. 10.8% of the patients were foreign nationalities. Previous exposure to Mycobacterium tuberculosis was present in 7.6% of patients, and 6.8% had history of previous TB infection. EPTB involvement was as follows: lymph nodes in 107(43.0%), pleura in 19(7.6%), other in 24(9.6%), urogenital system in 17(6.8%), sykeletal system in 29(11.6%), central nervous system in 19(7.6%), peritoneum in 24(9.6%), and skin in 10(4.0%). Cervical lymph nodes were the most frequently affected region, observed in 48 cases (19.3%). Acid-fast bacilli were identified in 13(5.2%) of 141 samples, Mycobacterium tuberculosis grew in culture of 57(22.9%) of 148 samples, and the polymerase chain reaction was positive for tuberculosis in 21(8.4%) of 84 samples. QuantiFERON was positive in 18.9% of patients. CONCLUSİON: For diagnosing EPTB, it's essential to maintain a high level of clinical suspicion and to use a combination of diagnostic methods, including mycobacterial culture and PCR and also pathological examination. |
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| ISSN: | 2213-7165 |