Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India
Community-acquired pneumonia (CAP) continues to pose a significant public health burden in India, particularly in the northeastern region, where data on microbial etiology and resistance patterns remain scarce. This cross-sectional observational analytical study, conducted over one year at a tertia...
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PAGEPress Publications
2025-06-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3549 |
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| author | Annu Gupta KG Lynrah Monaliza Lyngdoh Iadarilang Tiewsoh Baphiralyn Wankhar Debashis Priyadarshan Sahoo Bhupen Barman Mohammad Jamil Gwenette Andrea War |
| author_facet | Annu Gupta KG Lynrah Monaliza Lyngdoh Iadarilang Tiewsoh Baphiralyn Wankhar Debashis Priyadarshan Sahoo Bhupen Barman Mohammad Jamil Gwenette Andrea War |
| author_sort | Annu Gupta |
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Community-acquired pneumonia (CAP) continues to pose a significant public health burden in India, particularly in the northeastern region, where data on microbial etiology and resistance patterns remain scarce. This cross-sectional observational analytical study, conducted over one year at a tertiary care center in northeast India, analyzed 117 adult patients with clinico-radiologically confirmed CAP to elucidate their clinical, epidemiological, and microbiological profiles. The cohort was predominantly male (76.9%), with a mean age of 52 years, and the most affected age group was 31-40 years. Hypertension and chronic obstructive pulmonary disease were the most common comorbidities. Cough, breathlessness, and fever were the leading symptoms. Sputum cultures were positive in 42.7% of cases, with a striking predominance of gram-negative organisms (94%), especially Klebsiella pneumoniae and Pseudomonas species. Alarmingly, high resistance rates were observed for widely used antibiotics such as ceftriaxone and cefuroxime, while meropenem, amikacin, and ertapenem retained high sensitivity. These findings emphasize the critical need for tailored, region-specific empirical treatment strategies in light of emerging antibiotic resistance trends in CAP.
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| format | Article |
| id | doaj-art-6997f4fc42154eda9981fa31232ef983 |
| institution | Kabale University |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-6997f4fc42154eda9981fa31232ef9832025-08-20T03:50:11ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-06-0110.4081/monaldi.2025.3549Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast IndiaAnnu Gupta0https://orcid.org/0000-0001-8749-1620KG Lynrah1Monaliza Lyngdoh2Iadarilang Tiewsoh3https://orcid.org/0000-0002-8182-8904Baphiralyn Wankhar4https://orcid.org/0000-0003-0449-1831Debashis Priyadarshan Sahoo5https://orcid.org/0000-0002-6198-0626Bhupen Barman6https://orcid.org/0000-0002-5433-1310Mohammad Jamil7https://orcid.org/0000-0003-4758-8721Gwenette Andrea War8https://orcid.org/0000-0001-7135-1471All India Institute of Medical Sciences, GuwahatiNorth-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, ShillongNorth-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, ShillongNorth-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, ShillongNorth-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, ShillongAll India Institute of Medical Sciences, GuwahatiAll India Institute of Medical Sciences, GuwahatiAll India Institute of Medical Sciences, GuwahatiAll India Institute of Medical Sciences, Guwahati Community-acquired pneumonia (CAP) continues to pose a significant public health burden in India, particularly in the northeastern region, where data on microbial etiology and resistance patterns remain scarce. This cross-sectional observational analytical study, conducted over one year at a tertiary care center in northeast India, analyzed 117 adult patients with clinico-radiologically confirmed CAP to elucidate their clinical, epidemiological, and microbiological profiles. The cohort was predominantly male (76.9%), with a mean age of 52 years, and the most affected age group was 31-40 years. Hypertension and chronic obstructive pulmonary disease were the most common comorbidities. Cough, breathlessness, and fever were the leading symptoms. Sputum cultures were positive in 42.7% of cases, with a striking predominance of gram-negative organisms (94%), especially Klebsiella pneumoniae and Pseudomonas species. Alarmingly, high resistance rates were observed for widely used antibiotics such as ceftriaxone and cefuroxime, while meropenem, amikacin, and ertapenem retained high sensitivity. These findings emphasize the critical need for tailored, region-specific empirical treatment strategies in light of emerging antibiotic resistance trends in CAP. https://www.monaldi-archives.org/macd/article/view/3549Community-acquired pneumonianortheastern Indiabacteriological profileantibiotic resistanceempirical treatment |
| spellingShingle | Annu Gupta KG Lynrah Monaliza Lyngdoh Iadarilang Tiewsoh Baphiralyn Wankhar Debashis Priyadarshan Sahoo Bhupen Barman Mohammad Jamil Gwenette Andrea War Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India Monaldi Archives for Chest Disease Community-acquired pneumonia northeastern India bacteriological profile antibiotic resistance empirical treatment |
| title | Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India |
| title_full | Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India |
| title_fullStr | Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India |
| title_full_unstemmed | Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India |
| title_short | Study of the clinical profile of community-acquired pneumonia: a cross-sectional study in northeast India |
| title_sort | study of the clinical profile of community acquired pneumonia a cross sectional study in northeast india |
| topic | Community-acquired pneumonia northeastern India bacteriological profile antibiotic resistance empirical treatment |
| url | https://www.monaldi-archives.org/macd/article/view/3549 |
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