Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies

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Main Authors: Mourad Zerfaoui, Dharmeshkumar Patel, Yueqi Zhang, Raymond F. Schinazi, Youssef Errami
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02235-6
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author Mourad Zerfaoui
Dharmeshkumar Patel
Yueqi Zhang
Raymond F. Schinazi
Youssef Errami
author_facet Mourad Zerfaoui
Dharmeshkumar Patel
Yueqi Zhang
Raymond F. Schinazi
Youssef Errami
author_sort Mourad Zerfaoui
collection DOAJ
format Article
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institution DOAJ
issn 2059-3635
language English
publishDate 2025-05-01
publisher Nature Publishing Group
record_format Article
series Signal Transduction and Targeted Therapy
spelling doaj-art-698b8148043646f58f702f55dcd4caf92025-08-20T03:07:57ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352025-05-011011310.1038/s41392-025-02235-6Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapiesMourad Zerfaoui0Dharmeshkumar Patel1Yueqi Zhang2Raymond F. Schinazi3Youssef Errami4Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of AtlantaCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of AtlantaDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of AtlantaDepartment of Microbiology, Immunology, and Molecular Genetics, University of Californiahttps://doi.org/10.1038/s41392-025-02235-6
spellingShingle Mourad Zerfaoui
Dharmeshkumar Patel
Yueqi Zhang
Raymond F. Schinazi
Youssef Errami
Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
Signal Transduction and Targeted Therapy
title Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
title_full Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
title_fullStr Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
title_full_unstemmed Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
title_short Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies
title_sort loss of the aryl hydrocarbon receptor promotes cancer cell resistance to brafv600e targeted therapies
url https://doi.org/10.1038/s41392-025-02235-6
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