Pathophysiology of Myopenia in rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capacity and quality of life. RA accelerates musculoskeletal aging, leading to complications such as muscle degeneration and sarcopenia. Recent research has identified myopen...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-025-00438-9 |
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| author | Haiming Jin Gang Wang Qichen Lu Jessica Rawlins Junchun Chen Saanya Kashyap Oscar Charlesworth Dan Xu Lie Dai Sipin Zhu Jiake Xu |
| author_facet | Haiming Jin Gang Wang Qichen Lu Jessica Rawlins Junchun Chen Saanya Kashyap Oscar Charlesworth Dan Xu Lie Dai Sipin Zhu Jiake Xu |
| author_sort | Haiming Jin |
| collection | DOAJ |
| description | Abstract Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capacity and quality of life. RA accelerates musculoskeletal aging, leading to complications such as muscle degeneration and sarcopenia. Recent research has identified myopenia as a condition of significant muscle loss associated with illness, distinct from the muscle wasting seen in other chronic diseases like cancer cachexia or heart failure. In RA, myopenia is characterized by muscle depletion without concurrent significant fat loss, and it can affect individuals of all ages. While inflammation plays a central role, it is not the sole factor contributing to the high incidence of muscle wasting in RA. In subsequent discussions, secondary sarcopenia will be considered alongside myopenia, as both involve muscle wasting decline primarily due to disease. This review summarizes recent findings on the impact of RA-related myopenia and secondary sarcopenia on functional capacity, explores its underlying mechanisms, and discusses contemporary strategies to mitigate the process of musculoskeletal aging in RA patients. |
| format | Article |
| id | doaj-art-69898091f52644c7babb87d5f1420f2a |
| institution | OA Journals |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-69898091f52644c7babb87d5f1420f2a2025-08-20T02:10:34ZengNature Publishing GroupBone Research2095-62312025-06-0113111510.1038/s41413-025-00438-9Pathophysiology of Myopenia in rheumatoid arthritisHaiming Jin0Gang Wang1Qichen Lu2Jessica Rawlins3Junchun Chen4Saanya Kashyap5Oscar Charlesworth6Dan Xu7Lie Dai8Sipin Zhu9Jiake Xu10Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityShenzhen University of Advanced Sciences, and Shenzhen Institutes of Advanced Sciences Chinese Academy of SciencesDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversitySchool of Biomedical Sciences, The University of Western AustraliaShenzhen University of Advanced Sciences, and Shenzhen Institutes of Advanced Sciences Chinese Academy of SciencesSchool of Biomedical Sciences, The University of Western AustraliaSchool of Biomedical Sciences, The University of Western AustraliaSchool of Biomedical Sciences, The University of Western AustraliaDepartment of Rheumatology and Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capacity and quality of life. RA accelerates musculoskeletal aging, leading to complications such as muscle degeneration and sarcopenia. Recent research has identified myopenia as a condition of significant muscle loss associated with illness, distinct from the muscle wasting seen in other chronic diseases like cancer cachexia or heart failure. In RA, myopenia is characterized by muscle depletion without concurrent significant fat loss, and it can affect individuals of all ages. While inflammation plays a central role, it is not the sole factor contributing to the high incidence of muscle wasting in RA. In subsequent discussions, secondary sarcopenia will be considered alongside myopenia, as both involve muscle wasting decline primarily due to disease. This review summarizes recent findings on the impact of RA-related myopenia and secondary sarcopenia on functional capacity, explores its underlying mechanisms, and discusses contemporary strategies to mitigate the process of musculoskeletal aging in RA patients.https://doi.org/10.1038/s41413-025-00438-9 |
| spellingShingle | Haiming Jin Gang Wang Qichen Lu Jessica Rawlins Junchun Chen Saanya Kashyap Oscar Charlesworth Dan Xu Lie Dai Sipin Zhu Jiake Xu Pathophysiology of Myopenia in rheumatoid arthritis Bone Research |
| title | Pathophysiology of Myopenia in rheumatoid arthritis |
| title_full | Pathophysiology of Myopenia in rheumatoid arthritis |
| title_fullStr | Pathophysiology of Myopenia in rheumatoid arthritis |
| title_full_unstemmed | Pathophysiology of Myopenia in rheumatoid arthritis |
| title_short | Pathophysiology of Myopenia in rheumatoid arthritis |
| title_sort | pathophysiology of myopenia in rheumatoid arthritis |
| url | https://doi.org/10.1038/s41413-025-00438-9 |
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