Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery
Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been wide...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424001755 |
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| _version_ | 1850065288755675136 |
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| author | Quynh Dieu Trinh Huynh Nhu Mai Duc Toan Pham |
| author_facet | Quynh Dieu Trinh Huynh Nhu Mai Duc Toan Pham |
| author_sort | Quynh Dieu Trinh |
| collection | DOAJ |
| description | Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been widely studied. However, current therapeutics only reduce the symptoms and do not ameliorate the pathogenesis of these diseases. Recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. Mesenchymal stem cells (MSCs) exert anti-apoptotic, anti-inflammatory, and antioxidative effects. Therefore, investigating the effects of MSCs and their applications may lead to the discovery of more effective therapies for neurodegenerative diseases. In this study, we review different approaches used to identify therapies for neurodegenerative diseases using MSCs. |
| format | Article |
| id | doaj-art-6980835b17af4ac6a46355f054e92d4b |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-6980835b17af4ac6a46355f054e92d4b2025-08-20T02:49:02ZengElsevierRegenerative Therapy2352-32042024-06-012698198910.1016/j.reth.2024.09.014Application of mesenchymal stem cells for neurodegenerative diseases therapy discoveryQuynh Dieu Trinh0Huynh Nhu Mai1Duc Toan Pham2Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet NamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Viet NamFaculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Corresponding author.Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been widely studied. However, current therapeutics only reduce the symptoms and do not ameliorate the pathogenesis of these diseases. Recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. Mesenchymal stem cells (MSCs) exert anti-apoptotic, anti-inflammatory, and antioxidative effects. Therefore, investigating the effects of MSCs and their applications may lead to the discovery of more effective therapies for neurodegenerative diseases. In this study, we review different approaches used to identify therapies for neurodegenerative diseases using MSCs.http://www.sciencedirect.com/science/article/pii/S2352320424001755Neurodegenerative diseasesStem cell therapyMesenchymal stem cellsCircadian rhythmAntibody drugsNeuroinflammation |
| spellingShingle | Quynh Dieu Trinh Huynh Nhu Mai Duc Toan Pham Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery Regenerative Therapy Neurodegenerative diseases Stem cell therapy Mesenchymal stem cells Circadian rhythm Antibody drugs Neuroinflammation |
| title | Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| title_full | Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| title_fullStr | Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| title_full_unstemmed | Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| title_short | Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| title_sort | application of mesenchymal stem cells for neurodegenerative diseases therapy discovery |
| topic | Neurodegenerative diseases Stem cell therapy Mesenchymal stem cells Circadian rhythm Antibody drugs Neuroinflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424001755 |
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