Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study
Background: The standard approach for locally advanced cervical cancer is concurrent chemoradiation with platinum agents, preferably cisplatin. This study was aimed at comparing the treatment response and toxicity of carboplatin-based versus cisplatin-based concurrent chemoradiation in locally adva...
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Bangabandhu Sheikh Mujib Medical University
2025-05-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
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| Online Access: | https://www.banglajol.info/index.php/BSMMUJ/article/view/77007 |
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| author | Syed Md. Asadul Hoque Uday Kumar Sarkar Mohammad Rahamatullah Newton Kumar Sarker Md Jamal Uddin Md Abdul Bari |
| author_facet | Syed Md. Asadul Hoque Uday Kumar Sarkar Mohammad Rahamatullah Newton Kumar Sarker Md Jamal Uddin Md Abdul Bari |
| author_sort | Syed Md. Asadul Hoque |
| collection | DOAJ |
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Background: The standard approach for locally advanced cervical cancer is concurrent chemoradiation with platinum agents, preferably cisplatin. This study was aimed at comparing the treatment response and toxicity of carboplatin-based versus cisplatin-based concurrent chemoradiation in locally advanced carcinoma of the cervix.
Methods: This quasi-experimental study was conducted from September 2022 to August 2023 on 80 patients with locally advanced carcinoma cervix. Patients were divided evenly between the two arms (40 in each Arm). Arm A received weekly cisplatin 40 mg/m2, Arm B received weekly carboplatin with an area under the curve equal to 2 during external beam radiation. Then all the patients in both arms were treated by intracavity brachytherapy. Each patient was evaluated weekly during treatment and three months after the completion to assess treatment response and treatment related acute toxicities.
Results: After three months of completion of treatment, the response was statistically similar between arms [Arm A, 35 (87.5%) versus Arm B, 37 (92.5%), P=0.71]. In terms of toxicity, while Arm B had significantly less anaemia (P=0.03), vomiting (P=0.05), and renal toxicity (P=0.03) than Arm A. Other toxicities such as leucopenia, thrombocytopenia, nausea, hyponatremia, radiation-induced dermatitis, cystitis, proctitis, and diarrhea were similar between arms.
Conclusion: Concurrent chemoradiotherapy with carboplatin had a similar therapeutic response to concurrent chemoradiotherapy with cisplatin in locally advanced cervical cancer. Furthermore, the carboplatin arm had lesser toxicity than the cisplatin arm in terms of anaemia, vomiting, and renal toxicity.
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| format | Article |
| id | doaj-art-697b2b88664c4bb8a8a881c6aa1f5f9a |
| institution | DOAJ |
| issn | 2074-2908 2224-7750 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj-art-697b2b88664c4bb8a8a881c6aa1f5f9a2025-08-20T03:12:20ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502025-05-0118210.3329/bsmmuj.v18i2.77007Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental studySyed Md. Asadul Hoque0https://orcid.org/0009-0002-5209-9113Uday Kumar Sarkar1https://orcid.org/0009-0006-3909-9038Mohammad Rahamatullah2https://orcid.org/0009-0005-3624-8854Newton Kumar Sarker3https://orcid.org/0009-0004-9767-2512Md Jamal Uddin4https://orcid.org/0009-0007-0189-4519Md Abdul Bari5https://orcid.org/0000-0003-0292-3098Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Department of Clinical Oncology, Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University), Dhaka, Bangladesh Background: The standard approach for locally advanced cervical cancer is concurrent chemoradiation with platinum agents, preferably cisplatin. This study was aimed at comparing the treatment response and toxicity of carboplatin-based versus cisplatin-based concurrent chemoradiation in locally advanced carcinoma of the cervix. Methods: This quasi-experimental study was conducted from September 2022 to August 2023 on 80 patients with locally advanced carcinoma cervix. Patients were divided evenly between the two arms (40 in each Arm). Arm A received weekly cisplatin 40 mg/m2, Arm B received weekly carboplatin with an area under the curve equal to 2 during external beam radiation. Then all the patients in both arms were treated by intracavity brachytherapy. Each patient was evaluated weekly during treatment and three months after the completion to assess treatment response and treatment related acute toxicities. Results: After three months of completion of treatment, the response was statistically similar between arms [Arm A, 35 (87.5%) versus Arm B, 37 (92.5%), P=0.71]. In terms of toxicity, while Arm B had significantly less anaemia (P=0.03), vomiting (P=0.05), and renal toxicity (P=0.03) than Arm A. Other toxicities such as leucopenia, thrombocytopenia, nausea, hyponatremia, radiation-induced dermatitis, cystitis, proctitis, and diarrhea were similar between arms. Conclusion: Concurrent chemoradiotherapy with carboplatin had a similar therapeutic response to concurrent chemoradiotherapy with cisplatin in locally advanced cervical cancer. Furthermore, the carboplatin arm had lesser toxicity than the cisplatin arm in terms of anaemia, vomiting, and renal toxicity. https://www.banglajol.info/index.php/BSMMUJ/article/view/77007carboplatincisplatinconcurrent chemoradiotherapylocally advanced carcinoma cervix |
| spellingShingle | Syed Md. Asadul Hoque Uday Kumar Sarkar Mohammad Rahamatullah Newton Kumar Sarker Md Jamal Uddin Md Abdul Bari Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study Bangabandhu Sheikh Mujib Medical University Journal carboplatin cisplatin concurrent chemoradiotherapy locally advanced carcinoma cervix |
| title | Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study |
| title_full | Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study |
| title_fullStr | Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study |
| title_full_unstemmed | Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study |
| title_short | Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study |
| title_sort | effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix a quasi experimental study |
| topic | carboplatin cisplatin concurrent chemoradiotherapy locally advanced carcinoma cervix |
| url | https://www.banglajol.info/index.php/BSMMUJ/article/view/77007 |
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