Comprehensive In Vitro and In Silico Aerodynamic Analysis of High-Dose Ibuprofen- and Mannitol-Containing Dry Powder Inhalers for the Treatment of Cystic Fibrosis

Comprehensive In Vitro and In Silico Aerodynamic Analysis of High-Dose Ibuprofen- and Mannitol-Containing Dry Powder Inhalers for the Treatment of Cystic Fibrosis

<b>Background:</b> Cystic fibrosis is a hereditary disease, which causes the accumulation of dense mucus in the lungs accompanied by frequent local inflammation. The non-steroidal anti-inflammatory drug ibuprofen (IBU) and the mucolytic mannitol (MAN) can treat these symptoms. Compared t...

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Bibliographic Details
Main Authors: Petra Party, Zsófia Ilona Piszman, Árpád Farkas, Rita Ambrus
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
dry powder inhaler
mannitol
ibuprofen
wet milling
spray drying
Andersen Cascade Impactor
Online Access:https://www.mdpi.com/1999-4923/16/11/1465
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