High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis
<b>Background:</b> Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are, in essence, neurodegenerative disorders with significant individual, social, and economic burdens worldwide. Despite having different clinical onset and evolution, the two diseases share common risk f...
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MDPI AG
2025-01-01
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| Series: | Sclerosis |
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| Online Access: | https://www.mdpi.com/2813-3064/3/1/1 |
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| author | Thomas Gabriel Schreiner Liviu Iacob Cristina Georgiana Croitoru Diana Nicoleta Hodorog Dan Iulian Cuciureanu |
| author_facet | Thomas Gabriel Schreiner Liviu Iacob Cristina Georgiana Croitoru Diana Nicoleta Hodorog Dan Iulian Cuciureanu |
| author_sort | Thomas Gabriel Schreiner |
| collection | DOAJ |
| description | <b>Background:</b> Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are, in essence, neurodegenerative disorders with significant individual, social, and economic burdens worldwide. Despite having different clinical onset and evolution, the two diseases share common risk factors and underlying pathophysiological mechanisms. Environmental risk factors are particularly interesting, considering the available effective counter strategies. High-fat diets remain a significant element that negatively impacts the onset and evolution of several disorders, including ALS and MS. Focusing on changeable disease-related aspects is increasingly appealing in the context of a lack of an effective treatment. <b>Methods:</b> This review aims to offer an updated overview of the influence of high-fat diets in modulating the risk of onset and progression of ALS and MS, based on the search of three relevant online databases. <b>Results:</b> In the first part, the shared pathophysiological mechanisms of ALS and MS are shown, and significant differences between the two disorders are highlighted. Subsequently, the most relevant research on this topic conducted in animal models and humans is presented, bringing additional proof of the critical role of high-fat diets in neurodegeneration. Finally, based on current knowledge, the authors offer potential therapeutic approaches and future relevant research directions to better control nutrition in ALS and MS patients, hoping to increase survival and quality of life. <b>Conclusions:</b> High-fat diets negatively impact the onset and evolution of ALS and MS. |
| format | Article |
| id | doaj-art-696eebbbf66b4827acc151120bca0b38 |
| institution | Kabale University |
| issn | 2813-3064 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sclerosis |
| spelling | doaj-art-696eebbbf66b4827acc151120bca0b382025-08-20T03:49:22ZengMDPI AGSclerosis2813-30642025-01-0131110.3390/sclerosis3010001High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple SclerosisThomas Gabriel Schreiner0Liviu Iacob1Cristina Georgiana Croitoru2Diana Nicoleta Hodorog3Dan Iulian Cuciureanu4Department of Medical Specialties III, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFirst Neurology Clinic, “N. Oblu” Clinical Emergency Hospital, 700309 Iasi, RomaniaFirst Neurology Clinic, “N. Oblu” Clinical Emergency Hospital, 700309 Iasi, RomaniaDepartment of Medical Specialties III, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Specialties III, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<b>Background:</b> Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are, in essence, neurodegenerative disorders with significant individual, social, and economic burdens worldwide. Despite having different clinical onset and evolution, the two diseases share common risk factors and underlying pathophysiological mechanisms. Environmental risk factors are particularly interesting, considering the available effective counter strategies. High-fat diets remain a significant element that negatively impacts the onset and evolution of several disorders, including ALS and MS. Focusing on changeable disease-related aspects is increasingly appealing in the context of a lack of an effective treatment. <b>Methods:</b> This review aims to offer an updated overview of the influence of high-fat diets in modulating the risk of onset and progression of ALS and MS, based on the search of three relevant online databases. <b>Results:</b> In the first part, the shared pathophysiological mechanisms of ALS and MS are shown, and significant differences between the two disorders are highlighted. Subsequently, the most relevant research on this topic conducted in animal models and humans is presented, bringing additional proof of the critical role of high-fat diets in neurodegeneration. Finally, based on current knowledge, the authors offer potential therapeutic approaches and future relevant research directions to better control nutrition in ALS and MS patients, hoping to increase survival and quality of life. <b>Conclusions:</b> High-fat diets negatively impact the onset and evolution of ALS and MS.https://www.mdpi.com/2813-3064/3/1/1high-fat dietamyotrophic lateral sclerosismultiple sclerosisoxidative stressneuroinflammationanimal models |
| spellingShingle | Thomas Gabriel Schreiner Liviu Iacob Cristina Georgiana Croitoru Diana Nicoleta Hodorog Dan Iulian Cuciureanu High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis Sclerosis high-fat diet amyotrophic lateral sclerosis multiple sclerosis oxidative stress neuroinflammation animal models |
| title | High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis |
| title_full | High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis |
| title_fullStr | High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis |
| title_full_unstemmed | High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis |
| title_short | High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis |
| title_sort | high fat diet shared environmental risk factor for amyotrophic lateral sclerosis and multiple sclerosis |
| topic | high-fat diet amyotrophic lateral sclerosis multiple sclerosis oxidative stress neuroinflammation animal models |
| url | https://www.mdpi.com/2813-3064/3/1/1 |
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