Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies

Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as a promising therapeutic approach. However, a significant...

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Bibliographic Details
Main Authors: Dingtian Luo, Jing Zhou, Shuiliang Ruan, Binzhong Zhang, Huali Zhu, Yangming Que, Shijie Ying, Xiaowen Li, Yuanmin Hu, Zhengwei Song
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07385-7
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