Monoclonal gammopathy of renal significance: From bench to bedside
Monoclonal gammopathy of renal significance (MGRS) is a unique subset of plasma cell dyscrasias where monoclonal immunoglobulins (IG) cause kidney damage. Unlike monoclonal gammopathy of undetermined significance (MGUS), MGRS can have significant renal pathology and progressive renal damage. Because...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer –Medknow Publications
2025-01-01
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| Series: | Journal of Indira Gandhi Institute of Medical Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jigims.jigims_76_24 |
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| author | Megha Saigal Pulkit Khosla Arghya Chakraborty Amresh Krishna |
| author_facet | Megha Saigal Pulkit Khosla Arghya Chakraborty Amresh Krishna |
| author_sort | Megha Saigal |
| collection | DOAJ |
| description | Monoclonal gammopathy of renal significance (MGRS) is a unique subset of plasma cell dyscrasias where monoclonal immunoglobulins (IG) cause kidney damage. Unlike monoclonal gammopathy of undetermined significance (MGUS), MGRS can have significant renal pathology and progressive renal damage. Because of the wide range of diseases associated with MGRS, it poses a clinical challenge to accurately diagnose and treat this condition. B-lymphocyte cell clone-directed therapy, along with immunomodulatory agents if started at an early stage, can be beneficial in the management of this condition and preventing its progression to chronic kidney disease requiring renal replacement therapy. Here, we have conducted a literature review of all the data published on this topic of plasma cell disorders, MGRS and MGUS in the last two decades using an electronic database, relevant studies, journal articles, and textbooks to discuss regarding the latest updates on MGRS epidemiology, clinical features and treatment to help the nephrologist and general physicians in identifying and dealing with patients suffering from this condition. Furthermore, renal transplant indications and prognosis in such patients with chronic kidney failure have been discussed in this review article. |
| format | Article |
| id | doaj-art-696ac1da7fc642c4bbe0718f2fe20e6f |
| institution | DOAJ |
| issn | 2394-9031 2582-094X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer –Medknow Publications |
| record_format | Article |
| series | Journal of Indira Gandhi Institute of Medical Sciences |
| spelling | doaj-art-696ac1da7fc642c4bbe0718f2fe20e6f2025-08-20T03:11:48ZengWolters Kluwer –Medknow PublicationsJournal of Indira Gandhi Institute of Medical Sciences2394-90312582-094X2025-01-01111121910.4103/jigims.jigims_76_24Monoclonal gammopathy of renal significance: From bench to bedsideMegha SaigalPulkit KhoslaArghya ChakrabortyAmresh KrishnaMonoclonal gammopathy of renal significance (MGRS) is a unique subset of plasma cell dyscrasias where monoclonal immunoglobulins (IG) cause kidney damage. Unlike monoclonal gammopathy of undetermined significance (MGUS), MGRS can have significant renal pathology and progressive renal damage. Because of the wide range of diseases associated with MGRS, it poses a clinical challenge to accurately diagnose and treat this condition. B-lymphocyte cell clone-directed therapy, along with immunomodulatory agents if started at an early stage, can be beneficial in the management of this condition and preventing its progression to chronic kidney disease requiring renal replacement therapy. Here, we have conducted a literature review of all the data published on this topic of plasma cell disorders, MGRS and MGUS in the last two decades using an electronic database, relevant studies, journal articles, and textbooks to discuss regarding the latest updates on MGRS epidemiology, clinical features and treatment to help the nephrologist and general physicians in identifying and dealing with patients suffering from this condition. Furthermore, renal transplant indications and prognosis in such patients with chronic kidney failure have been discussed in this review article.https://journals.lww.com/10.4103/jigims.jigims_76_24monoclonal gammopathy of renal significancemonoclonal gammopathy of undetermined significancemultiple myeloma |
| spellingShingle | Megha Saigal Pulkit Khosla Arghya Chakraborty Amresh Krishna Monoclonal gammopathy of renal significance: From bench to bedside Journal of Indira Gandhi Institute of Medical Sciences monoclonal gammopathy of renal significance monoclonal gammopathy of undetermined significance multiple myeloma |
| title | Monoclonal gammopathy of renal significance: From bench to bedside |
| title_full | Monoclonal gammopathy of renal significance: From bench to bedside |
| title_fullStr | Monoclonal gammopathy of renal significance: From bench to bedside |
| title_full_unstemmed | Monoclonal gammopathy of renal significance: From bench to bedside |
| title_short | Monoclonal gammopathy of renal significance: From bench to bedside |
| title_sort | monoclonal gammopathy of renal significance from bench to bedside |
| topic | monoclonal gammopathy of renal significance monoclonal gammopathy of undetermined significance multiple myeloma |
| url | https://journals.lww.com/10.4103/jigims.jigims_76_24 |
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